Effects of Walnut Consumption on Lipid Profile of Female Undergraduate Students

Document Type: Research Paper

Authors

1 Faculty of Nursing and Midwifery, Islamic Azad University, Bojnurd, Iran.

2 Department of Public Health, North Khorasan University of Medical Sciences, Bojnurd, Iran

3 Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Department of Anesthesiology and Reanimation, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Department of Nutrition, School of Medicine, Mashhad University of medical Sciences, Mashhad; and Department of Public Health, North Khorasan University of medical Sciences, Bojnurd, Iran.

Abstract

Introduction: Cardiovascular disease (CVD) is now an important cause of death all over the world and is a growing health concern. Lifestyle factors, including nutrition, have an undeniable effect on the prevention and treatment of CVD. Walnut has a unique profile and is rich in polyunsaturated fatty acids, which may improve blood lipids and CVD risk factors. Method: A randomized clinical trial, in which 50 participants with a normal lipid profile were randomly divided into two groups. We added 40 gr of walnuts without skin per day for 4 weeks to the usual diet of the intervention group. Results: Paired T-test showed that calorie, protein and fat intake increased significantly in all of the cases, after the consumption of walnuts. At baseline, BMI in control and intervention groups was 21.66 ± 4.06 and 21.22± 4.03 respectively which did not have a significant difference before and after the intervention. We observed a significant decrease in serum LDL and TG concentration in walnut groups after the intervention. Conclusion: The consumption of walnuts could result in decreased serum LDL and TG.

Keywords


1. WHO.CVD. https://wwwwhoint/cardiovascular_diseases/en/. 2019.

2. Aronis KN, Vamvini MT, Chamberland JP, Sweeney LL, Brennan AM, Magkos F, et al. Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study. Metabolism: clinical and experimental. 2012 Apr;61(4):577-82. PubMed PMID: 22075273. Pubmed Central PMCID: PMC3645917. Epub 2011/11/15. eng.

3. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics—2016 update: a report from the American Heart Association. Circulation. 2015:CIR. 0000000000000350.

4. Farvid MS, Malekshah AF, Pourshams A, Poustchi H, Sepanlou SG, Sharafkhah M, et al. Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study. American journal of epidemiology. 2017 Apr 15;185(8):697-711. PubMed PMID: 28369205. Pubmed Central PMCID: PMC5860026. Epub 2017/04/04. eng.

5. Asgary S, Rastqar A, Keshvari M. Functional Food and Cardiovascular Disease Prevention and Treatment: A Review. Journal of the American College of Nutrition. 2018 Jul;37(5):429-55. PubMed PMID: 29528772. Epub 2018/03/13. eng.

6. Torabian S, Haddad E, Cordero-MacIntyre Z, Tanzman J, Fernandez ML, Sabate J. Long-term walnut supplementation without dietary advice induces favorable serum lipid changes in free-living individuals. European journal of clinical nutrition. 2010 Mar;64(3):274-9. PubMed PMID: 20087377. Epub 2010/01/21. eng.

7. Hu FB, Stampfer MJ, Manson JE, Rimm EB, Colditz GA, Rosner BA, et al. Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. BMJ (Clinical research ed). 1998 Nov 14;317(7169):1341-5. PubMed PMID: 9812929. Pubmed Central PMCID: PMC28714. Epub 1998/11/13. eng.

8. Sabate J, Fraser GE, Burke K, Knutsen SF, Bennett H, Lindsted KD. Effects of walnuts on serum lipid levels and blood pressure in normal men. The New England journal of medicine. 1993 Mar 4;328(9):603-7. PubMed PMID: 8357360. Epub 1993/03/04. eng.

9. Eslamparast T, Sharafkhah M, Poustchi H, Hashemian M, Dawsey SM, Freedman ND, et al. Nut consumption and total and cause-specific mortality: results from the Golestan Cohort Study. International journal of epidemiology. 2017 Feb 1;46(1):75-85. PubMed PMID: 26946539. Pubmed Central PMCID: PMC5837191. Epub 2016/03/08. eng.

10. Mirmiran P, Bahadoran Z, Khalili Moghadam S, Zadeh Vakili A, Azizi F. A Prospective Study of Different Types of Dietary Fiber and Risk of Cardiovascular Disease: Tehran Lipid and Glucose Study. Nutrients. 2016 Nov 7;8(11). PubMed PMID: 27827978. Pubmed Central PMCID: PMC5133074. Epub 2016/11/10. eng.

11. Damasceno NR, Perez-Heras A, Serra M, Cofan M, Sala-Vila A, Salas-Salvado J, et al. Crossover study of diets enriched with virgin olive oil, walnuts or almonds. Effects on lipids and other cardiovascular risk markers. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2011 Jun;21 Suppl 1:S14-20. PubMed PMID: 21421296. Epub 2011/03/23. eng.

12. Spaccarotella KJ, Kris-Etherton PM, Stone WL, Bagshaw DM, Fishell VK, West SG, et al. The effect of walnut intake on factors related to prostate and vascular health in older men. Nutrition journal. 2008 May 2;7:13. PubMed PMID: 18454862. Pubmed Central PMCID: PMC2412899. Epub 2008/05/06. eng.

13. Iwamoto M, Sato M, Kono M, Hirooka Y, Sakai K, Takeshita A, et al. Walnuts lower serum cholesterol in Japanese men and women. The Journal of nutrition. 2000 Sep;130(9):2407. PubMed PMID: 10958843. Epub 2000/08/26. eng.

14. O'Neil CE, Keast DR, Nicklas TA, Fulgoni VL, 3rd. Out-of-hand nut consumption is associated with improved nutrient intake and health risk markers in US children and adults: National Health and Nutrition Examination Survey 1999-2004. Nutrition research (New York, NY). 2012 Mar;32(3):185-94. PubMed PMID: 22464805. Epub 2012/04/03. eng.

15. Torabian S, Haddad E, Rajaram S, Banta J, Sabate J. Acute effect of nut consumption on plasma total polyphenols, antioxidant capacity and lipid peroxidation. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. 2009 Feb;22(1):64-71. PubMed PMID: 19192028. Epub 2009/02/05. eng.

16. Jenkins DJ, Kendall CW, Josse AR, Salvatore S, Brighenti F, Augustin LS, et al. Almonds decrease postprandial glycemia, insulinemia, and oxidative damage in healthy individuals. The Journal of nutrition. 2006 Dec;136(12):2987-92. PubMed PMID: 17116708. Epub 2006/11/23. eng.

17. Jiang R, Jacobs DR, Jr., Mayer-Davis E, Szklo M, Herrington D, Jenny NS, et al. Nut and seed consumption and inflammatory markers in the multi-ethnic study of atherosclerosis. American journal of epidemiology. 2006 Feb 1;163(3):222-31. PubMed PMID: 16357111. Epub 2005/12/17. eng.

18. Din JN, Aftab SM, Jubb AW, Carnegy FH, Lyall K, Sarma J, et al. Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans. European journal of clinical nutrition. 2011 Feb;65(2):234-9. PubMed PMID: 21048773. Pubmed Central PMCID: PMC3033322. Epub 2010/11/05. eng.

19. Kris-Etherton PM, Yu-Poth S, Sabate J, Ratcliffe HE, Zhao G, Etherton TD. Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk. The American journal of clinical nutrition. 1999 Sep;70(3 Suppl):504s-11s. PubMed PMID: 10479223. Epub 1999/09/09. eng.

20. de Lorgeril M, Salen P. Alpha-linolenic acid and coronary heart disease. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2004 Jun;14(3):162-9. PubMed PMID: 15330276. Epub 2004/08/28. eng.

21. Guasch-Ferre M, Li J, Hu FB, Salas-Salvado J, Tobias DK. Effects of walnut consumption on blood lipids and other cardiovascular risk factors: an updated meta-analysis and systematic review of controlled trials. The American journal of clinical nutrition. 2018 Jul 1;108(1):174-87. PubMed PMID: 29931130. Epub 2018/06/23. eng.

22. Kris-Etherton PM. Walnuts decrease risk of cardiovascular disease: a summary of efficacy and biologic mechanisms. The Journal of nutrition. 2014 Apr;144(4 Suppl):547s-54s. PubMed PMID: 24500935. Epub 2014/02/07. eng.

23. Kim H, Yokoyama W, Davis PA. TRAMP prostate tumor growth is slowed by walnut diets through altered IGF-1 levels, energy pathways, and cholesterol metabolism. Journal of medicinal food. 2014;17(12):1281-6.