The Effect of Resistance Training On Serum Adropin, Fetuin-A, and Insulin Resistance in Overweight Women

Document Type : Research Paper

Authors

1 Ph.D. Candidate, Department of exercise physiology, ST.C., Islamic Azad university, Tehran, Iran.

2 Associated Professor, Department of exercise physiology, ST.C., Islamic Azad university, Tehran, Iran.

3 Assistant Professor, Department of Physical Education and Sports Sciences, Parand Branch, Islamic Azad University, Tehran, Iran.

Abstract

Introduction: Overweight is associated with disturbances in serum levels of adipokines and cytokines that affect metabolism and insulin action.In this study, we aimed to assess the effect of resistance training on serum adropin, fetuin-A, and insulin resistance in sedentary overweight women. Methods: In this quasi-experimental study, 24 overweight women aged 25-35 (BMI between 26 and 30) were randomly divided into exercise and control groups. The exercise group participated in an 8-week resistance training program (three times per week), while the control group continued their sedentary lifestyle. Fasting blood samples were obtained from the brachial vein before the training program and 48 hours after the final exercise session to measure serum adropin, fetuin-A, glucose, insulin, and insulin resistance. Results were then compared between the two groups. Results: Resistance training resulted in a significant decrease in serum fetuin-A (p=0.014), glucose (p=0.003), and insulin resistance (p=0.011), and a significant increase in serum adropin (p=0.021). No significant changes were observed in the control group for fetuin-A (p=0.413), glucose (p=0.351), adropin (p=0.539), or insulin resistance (p=0.137). Conclusion: Based on our findings, improvements in insulin resistance can be attributed to changes in serum adropin and fetuin-A in response to resistance training. Identifying the mechanisms responsible for these changes requires further studies in this field.

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References

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Journal of Nutrition,Fasting and Health
Volume 13, Issue 4
October 2025
Pages 244-250

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History

  • Receive Date: 02 December 2024
  • Revise Date: 28 December 2024
  • Accept Date: 04 January 2025

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