TY - JOUR ID - 13612 TI - The Effects of Endurance Training and Vitamin D Supplementation on the Bone Resorption Markers in the Rats Exposed to Oxidative Damage Induced by Hydrogen Peroxide (H2O2) JO - Journal of Nutrition,Fasting and Health JA - JNFH LA - en SN - AU - Shariati, Marina AU - Azarbayjani, Mohammad Ali AU - Kaka, Gholam Reza AU - Zilaei Bouri, Shirin AD - PhD of Exercise physiology, Shoushtar Branch, Islamic Azad University (I.A.U), Shoushtar, Iran AD - Professor of Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University (I.A.U), Tehran, Iran AD - Associate Professor of Neurosciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran AD - Assistant Professor, Department of Physical Education & Sport Sciences , Masjed-Soleiman Branch, Islamic Azad University (I.A.U), Masjed-Soleiman, Iran Y1 - 2020 PY - 2020 VL - 8 IS - 1 SP - 40 EP - 47 KW - Training KW - Vitamin D KW - Bone KW - H2O2 DO - 10.22038/jnfh.2019.41061.1202 N2 - Introduction:studies have shown that the increase of active oxygen species is associated with damage to bone cells and the role of exercise and vitamin D on bone health has been proven;the aim of this study was to investigate the interactive effects of aerobic exercise with vitamin D supplements on bone resorption markers in rats exposed to oxidative damage induced by H2O2. Methods: Sixty male adult male Wistar rats were randomly divided into 10 groups of six rats including:1)1 mmol/kg H2O2, 2)2 mmol/kg H2O2, 3)1mmol/kg H2O2+vitamin D,4) 1mmol/kg H2O2+aerobic training,5)1mmol/kg H2O2+Vitamin D+aerobic training,6)2 mmol/kg H2O2+Vitamin D,7)2mmol/kg H2O2+aerobic training,8)2mmol/kg H2O2+Vitamin D+aerobic training;9)Sham (D-methyl- Sulfoxide+normal saline); and(10)control and for 8 weeks were under the protocol of intervention.The levels of TRACP/5B and NTX were measured by ELISA method. Two-way and one-way ANOVA with Tukey’s post hoc test was used to analysis of data (p≤0.05). Results: 1and 2 mmol/kg H2O2 had no significant effect on NTX and TRACP/5B levels(p≥0/05). Eight weeks of aerobic training increased of NTX levels in rats exposed to 2mmol/kg H2O2 (p≤0/05).Eight weeks of Vitamine D had no significant effect on NTX and TRACP/5B levels (p≥0/05).Also eight weeks of aerobic training along with Vitamin D had no interactive effects on increase of NTX and TRACP/5B levels in rats exposed to 1and 2mmol/kg H2O2(p≥0/05). Conclusion: It seems that doses of 1 and 2mg/kg H2O2 have not significant effect on changes in bone resorption markers,but aerobic exercise had a significant effect on NTX increase in rats exposed to oxidative damage induced by 2mg/kg H2O2. UR - https://jnfh.mums.ac.ir/article_13612.html L1 - https://jnfh.mums.ac.ir/article_13612_fe206f3d57bf0bafb18f9bdd50dc947d.pdf ER -