<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Journal of Nutrition,Fasting and Health</title>
			<title_fa></title_fa>
			<short_title>JNFH</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://jnfh.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn></journal_id_issn>
			<journal_id_issn_online>2821-2746</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>9</month>
				<day>1</day>
			</pubdate>
			<volume>14</volume>
			<number>3</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>The Supplementation of L-Arginine, When Combined with High-Intensity Interval Training, Leads to Superior Improvements in Inflammatory Status Among Football Players</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Introduction: Optimizing post-exercise recovery and mitigating metabolic stress are central challenges in competitive sports. Limited data currently exist concerning the synergistic impact of high-intensity interval training (HIIT) and L-Arginine on immune-metabolic regulation in footballer players. This study aimed to compare the effects of six weeks of combined HIIT and L-Arginine supplementation on inflammatory/anti-inflammatory indices, hepatic enzymes, and key physical and skill performance factors. Methods: Twenty male football players were randomly divided into two intervention groups: HIIT plus L-Arginine (HIIT+ARG) and HIIT plus placebo (HIIT+PL). The six-week intervention involved three training sessions per week, with progressive HIIT intensity reaching 110% of maximal aerobic speed (MAS) by weeks 5-6. The HIIT+ARG group consumed 6 grams of L-Arginine daily. Data were analyzed using covariance (ANCOVA).  All statistical analyses for this study were conducted using SPSS software (version 26). The statistical significance level was set at P &lt; 0.05. Results: The results of the analysis of covariance, controlling for pre-test values, revealed a significant between-group difference at the post-test stage regarding interleukin-10 levels (IL-10) (F = 11.31, P = 0.004) and alanine aminotransferase (F = 4.94, P = 0.04); specifically, the &#039;exercise + supplement&#039; group exhibited more favorable improvements compared to the placebo group. However, after adjusting for baseline values, no significant between-group differences were observed in interleukin-6 (F = 3.20, P = 0.09) or aspartate aminotransferase levels (F = 2.88, P = 0.107). Within the HIIT+ARG group, IL-6 (P=002), ALT (P= 0.043), and AST (P= 0.005) all significantly decreased, while IL-10 significantly increased (P= 0.001). Concurrently, this combined regimen resulted in significant functional gains: anaerobic power and VO2max significantly improved, and agility and dribbling/shooting time significantly decreased (indicating performance enhancement). The HIIT+PL group showed no significant change in these markers. Conclusion: The simultaneous use of HIIT and L-Arginine induced a significant dual-directional modulation of immune and metabolic markers, alongside notable functional gains in anaerobic capacity and agility performance. These findings underscore the specific benefit of L-Arginine as an ergogenic aid; therefore, coaches and athletes are recommended to incorporate this combined approach to enhance metabolic health and functional capacity.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Interval training, L-arginine, Inflammatory markers, Liver enzymes, Football players</keyword>
				<start_page>190</start_page>
				<end_page>202</end_page>
				<web_url>https://jnfh.mums.ac.ir/article_27403.html</web_url>
			<author_list><author>
				<first_name>Mohsen</first_name>
				<middle_name></middle_name>
				<last_name>Sadrtalab</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sadrtalab@gmail.com</email>
				<code>120376</code>
				<coreauthor>No</coreauthor>
				<affiliation>MSc in Sport Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Keyvan</first_name>
				<middle_name></middle_name>
				<last_name>Hejazi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>k.hejazi@hsu.ac.ir</email>
				<code>120375</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Associate Professor in Sport Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hamid</first_name>
				<middle_name></middle_name>
				<last_name>Marafeti</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>m.marafeti4@hsu.ac.ir</email>
				<code>120377</code>
				<coreauthor>No</coreauthor>
				<affiliation>Associate Professor in Sport Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>