Probiotic Consumption, Fatigue, and Glycemic Control in Patients with Type 2 Diabetes: A Cross-Sectional Study

Document Type : Research Paper

Authors

1 Vocational School of Health Services, Department of Medical Services and Techniques, Sivas Cumhuriyet University, Sivas, Turkey.

2 Sakarya University of Applied Sciences, Faculty of Health Sciences, Sakarya, Turkey.

3 Susehri School of Health Nursing Department, Sivas Cumhuriyet University, Sivas, Turkey.

Abstract

Introduction: Probiotics have recently been included in nutritional recommendations for achieving glycemic control in diabetic patients. Probiotic foods are not standardized, and their effectiveness can vary significantly between products and species. Therefore, the results of this study may not be generalizable to all probiotics consumed. This study aimed to determine the consumption of probiotics by type 2 diabetes patients and the relationship between probiotic consumption and their fatigue levels and glycemic control. Methods: This study was conducted in a university hospital in the Central Anatolian Region of Turkey. A total of 235 diabetic patients were included in the cross-sectional study. Data were collected using a patient information form, a self-report probiotic consumption information form, and the Visual Analog Scale for Fatigue. Results: The majority of the patients (83.4%) consumed probiotic products, and the most frequently consumed probiotic products by them were yogurt (80%), ayran (67.7%), and pickles (57.9%). The fatigue levels of probiotic-consuming and non-consuming patients were similar (p > 0.05), but the energy levels of probiotic-consuming patients were higher (p<0.05). The fasting blood glucose and HbA1c levels of the patients taking probiotics were low, but this difference was insignificant (p>0.05). Conclusion: Since probiotics are beneficial to diabetes patients, it is essential to provide information about them and support the use of probiotics per expert recommendations.

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Main Subjects

References

  1. Celebi F, Sanlier N. Probiotics, prebiotics and diabetes mellitus. Clinical Medicine Journal of Family Medicine. 2019; 11(2):63-70.
  2. Clinical Practice Guideline for Diagnosis, Treatment and Follow-up of Diabetes Mellitus and Its Complications. The Socıety of Endocrınology and Metabolism of Turkey (SEMT) English Version of the 12th Edition, Ankara. 2019.
  3. Altun HK, Yıldız EA. Relationship between prebiotics-probiotics and diabetes mellitus. Turkish Journal of Life Sciences. 2017; 2(1):149-56.
  4. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. Expert consensus document. The International Scientific Association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014; 11(8):506-14.
  5. Kamarli H. Pre- probiotics and diabetes. Bes Diy Derg. 2019; 47(Special Issue):92-101.
  6. Panwar H, Rashmi HM, Batish VK, Grover S. Probiotics as potential biotherapeutics in the management of type 2 diabetes - prospects and perspectives. Diabetes Metab Res Rev. 2013; 29(2):103-12.
  7. Idzior-Waluś B, Waluś-Miarka, M. Is now the time for probiotics in diabetes management?. Polskie Archiwum Medycyny Wewnetrznej. 2015; 125.
  8. Kellow NJ, Coughlan MT, Reid CM. Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials. Br J Nutr. 2014;111(7):1147-61.
  9. Rabiee MR, Babajafari S. Probiotics and diabetes: A review. Int J Nutr Sci. 2018; 3(2):73-81.
  10. Wang X, Juan QF, He YW, Zhuang L, Fang YY, Wang YH. Multiple effects of probiotics on different types of diabetes: A systematic review and meta-analysis of randomized, placebo controlled trials. J Pediatr Endocrinol Metab. 2017; 30:611-22.
  11. Sun J, Buys NJ. Glucose- and glycaemic factor-lowering effects of probiotics on diabetes: A meta-analysis of randomised placebo-controlled trials. Br J Nutr. 2016; 115:1167-77.
  12. Tao YW, Gu YL, Mao XQ, Zhang L, Pei YF. Effects of probiotics on type II diabetes mellitus: a meta-analysis. J Transl Med. 2020; 18(1):30.
  13. Rittiphairoj T, Pongpirul K, Janchot K, Mueller NT, Li T. Probiotics contribute to glycemic control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Adv Nutr. 2021;12(3):722-34.
  14. Imamlı H, Akca, F. Effects of probiotics supplementation on health and exercise performance. SPORMETRE Journal of Physical Education and Sports Sciences. 2018;16(2):196-208.
  15. Ozgül AA, Bozat C, Seziş M, Badur Y, Özcan ÖÖ, Sarıyer ET, Çevik E, Çolak H, Karahan M. Determination of knowledge level and consumption status of individuals in working life about probiotic foods. Istanbul Gelisim University Journal of Health Sciences. 2020;12: 365-78.
  16. Karahasan Mercan S. Relationship between frequency of urinary tract infection and probiotic product use in diabetics mellitus patients. 19 Mayis University, (Master Thesis), Samsun. 2019.
  17. Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V. Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition. 2012; 28: 539–43.
  18. Asemi Z, Zare Z, Shakeri H, Sabihi SS, Esmaillzadeh A. Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes. Ann Nutr Metab. 2013; 63(1-2):1-9.
  19. Yadav H, Jain S, Sinha PR: Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition. 2007; 23: 62–8.
  20. Naruszewicz M, Johansson ML, ZapolskaDownar D, Bukowska H: Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers. Am J Clin Nutr. 2002; 76:1249–55
  21. Shane-McWhorter L. Dietary supplements and probiotics for diabetes. Am J Nurs. 2012;112(7):47-53.
  22. Kalra S, Sahay R. Diabetes fatigue syndrome. Diabetes Ther. 2018;9(4):1421-9.
  23. Singh R, Teel C, Sabus C, McGinnis P, Kluding P. Fatigue in type 2 diabetes: Impact on quality of life and predictors. PLoS ONE. 2016; 11(11):e0165652.
  24. Bayram D, Demir Y. Effect of fatigue and sleep quality on the quality of life in patient with type 2 diabetes. Turkiye Klinikleri J Nurs Sci. 2016; 8(2):131-9.
  25. Hillson R. Fatigue and tiredness in diabetes. Practical Diabetes. 2020; 37(2):45-6.
  26. Saglam A. Probiotics are a cure for many diseases. Journal of Food and Nutrition. 18(2): 36-9.
  27. Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V. Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition. 2012; 28(5):539-43.
  28. Asemi Z, Zare Z, Shakeri H, Sabihi SS, Esmaillzadeh A. Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes. Ann Nutr Metab. 2013; 63(1-2):1-9.
  29. Mohamadshahi M, Veissi M, Haidari F, Shahbazian H, Kaydani GA, Mohammadi F. Effects of probiotic yogurt consumption on inflammatory biomarkers in patients with type 2 Bioimpacts. 2014; 4(2):83-8.
  30. Mahboobi S, Rahimi F, Jafarnejad S. Effects of prebiotic and synbiotic supplementation on glycaemia and lipid profile in type 2 diabetes: A meta-analysis of randomized controlled trials. Adv Pharm Bull. 2018; 8(4):565-74.
  31. Sabico S, Al-Mashharawi A, Al-Daghri NM, Wani K, Amer OE, Hussain DS, Ahmed Ansari MG, Masoud MS, Alokail MS, McTernan PG. Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 2019;38(4):1561-9.
  32. Kijmanawat A, Panburana P, Reutrakul S, Tangshewinsirikul C. Effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: A double-blind randomized controlled trial. J Diabetes Investig. 2019;10(1):163-70.
  33. Jiang H, Zhang Y, Xu D, Wang Q. Probiotics ameliorates glycemic control of patients with diabetic nephropathy: A randomized clinical study. J Clin Lab Anal. 2021;35(4):e23650.
  34. Lee KA, Hicks G, Nino-Murcia G. Validity and reliability of a scale to assess fatigue. Psychiatry Res. 1991; 36(3):291-8.
  35. Yurtsever S, Bedük T. Evaluation of fatigue on hemodialysis patients. Journal of Research and Development in Nursing. 2003; 2: 3-12
  36. Aslan S, Kara R, Yaman H. Determining the Consumption Habits Related to Probiotic Products. Turk J Agric Food Sci Technol. 2019; 7(6):861-5.
  37. Kağan DA, Özlü T, Yurttaş H. A research on the knowledge and consumption of probiotic foods in adults. Eur J Lipid Sci Technol. 2019; 17:556-63.
  38. Pehlivan B. Evaluation frequency of adults probiotic food consumption and levels of knowledge. Scientific Journal of Complementary Medicine, Regulation and Neural Therapy .2020; 14(3):75-85.
  39. Betz M, Uzueta A, Rasmussen H, Gregoire M, Vandrwall C, Witowich G. Knowledge, use and perceptions of probiotics and prebiotics in hospitalized patients. Nutrition and Health Sciences. 2015; 72: 261-6.
  40. Mirmiran P, Bahadoran Z, Azizi F. Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review. World J Diabetes. 2014;5:267-81.
  41. Manzoor MS, Mustafa ZU. Prebiotics and their activity for the handling of diabetes: Literature review. J Food Sci Nutr The. 2019;5(1):7-10.
  42. Cheng LH, Liu YW, Wu CC, Wang S, Tsai YC. Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders. J Food Drug Anal. 2019; 27(3):632-48.
  43. Sharma A, Wakode S, Sharma S, Fayaz F. Role of Gut Microbiota and Probiotic in Chronic Fatigue Syndrome. Probiotic Research in Therapeutics. 2022;4: 211-36.
  44. Marotta A, Sarno E, Del Casale A, Pane M, Mogna L, Amoruso A, Felis GE, Fiorio M. Effects of probiotics on cognitive reactivity, mood, and sleep quality. Front Psychiatry. 2019;10:164.

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History

  • Receive Date: 11 October 2023
  • Revise Date: 22 November 2023
  • Accept Date: 25 November 2023

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