Endurance Training and Royal Jelly Consumption Effects on Dopamine in Rats with Alzheimer's disease

Document Type : Research Paper

Authors

Department of Physical Education and Sport Sciences, Eslamshahr Branch, Islamic Azad University, Eslamshahr, Iran

Abstract

Introduction: Alzheimer's disease may be a sort of amnesia with brain dysfunction that gradually degrades the patient's mental abilities. The purpose of this study was to research the effect of endurance training with royal jelly consumption on dopamine in the hippocampus tissue of Alzheimer's rats with trimethyltin. Methods: During this study, 30 rats underwent injection of 8 milligram / Kilograms trimethyltin chloride and were divided into groups of 6 rats: control, training, royal jelly consumption, and training with royal jelly consumption. 6 rats were included in the healthy control group to be evaluated the effects of Alzheimer's induction on dopamine levels. The training groups were active on the treadmill for 8 weeks. The royal jelly consumption groups received 100 milligram / Kilograms royal jelly per day peritoneally for 8 weeks. The Kolmogorov-Smirnov, one-way ANOVA, and Tukey’s post hoc tests were used to analyze the findings. (P ≤0.05). Results: Alzheimer's induction with trimethyltin toxin had a Significant Impact on reducing dopamine gene levels (P = 0.04); royal jelly, training, and training with royal jelly consumption had a significant effect on increasing dopamine gene expression levels (P = 0.001). Also, the effect of training with Royal Jelly was greater than training or royal jelly consumption alone. (P = 0.001) Conclusions: Although training and royal jelly consumption improve dopamine gene expression levels in the hippocampus tissue of rats with Alzheimer's disease, the effects of training combined with royal jelly consumption appear to be greater than those of royal jelly consumption alone.

Keywords

References

1. Avila J, Llorens-Martín M, Pallas-Bazarra N, Bolós M, Perea JR, Rodríguez-Matellán A, et al. Cognitive decline in neuronal aging and Alzheimer's disease: role of NMDA receptors and associated proteins. Frontiers in neuroscience. 2017;11:626.
2. García-Mesa Y, López-Ramos JC, Giménez-Llort L, Revilla S, Guerra R, Gruart A, et al. Physical exercise protects against Alzheimer's disease in 3xTg-AD mice. Journal of Alzheimer's Disease. 2011;24(3):421-54.
3. Thal DR, Walter J, Saido TC, Fändrich M. Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease. Acta neuropathologica. 2015;129(2):167-82.
4. Teixeira AM, Trevizol F, Colpo G, Garcia SC, Charão M, Pereira RP, et al. Influence of chronic exercise on reserpine-induced oxidative stress in rats: behavioral and antioxidant evaluations. Pharmacology Biochemistry and Behavior. 2008;88(4):465-72.
5. Capucho PHFV, Brucki SMD. Judgment in mild cognitive impairment and Alzheimer's disease. Dementia & neuropsychologia. 2011;5(4):297-302.
6. Kolb B, Whishaw IQ. Fundamentals of human neuropsychology: Macmillan; 2009.
7. Sun ZP, Gong L, Huang SH, Geng Z, Cheng L, Chen ZY. Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells. J Neurochem. 2011;117(1):121-32.
8. Albertazzi P. Noradrenergic and serotonergic modulation to treat vasomotor symptoms. British Menopause Society Journal. 2006;12(1):7-11.
9. Franzoni F, Federighi G, Fusi J, Cerri E, Banducci R, Petrocchi A, et al. Physical exercise improves total antioxidant capacity and gene expression in rat hippocampal tissue. Arch Ital Biol. 2017;155(1/2):1-10.
10. Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S. Royal jelly-induced neurite outgrowth from rat pheochromocytoma PC12 cells requires integrin signal independent of activation of extracellular signalregulated kinases. J Biomed Res. 2007;28(3):139-46.
11. Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, propolis, and royal jelly: a comprehensive review of their biological actions and health benefits. Oxidative Medicine And Cellular Longevity. 2017;2017.
12. Zamani Z, Reisi P, Alaei H, Pilehvarian AA. Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease. Advanced Biomedical Research. 2012;1.
13. Osali A, Mostafavi H, Moaseri F. The Effect of Twelve-Week Aerobic Exercise on IL-6 level and depression in 50-65 Years Old Women with Syndrome Metabolic. Majallah-i pizishki-i Danishgah-i Ulum-i Pizishki va Khadamat-i Bihdashti-i Darmani-i Tabriz. 2018;40(3):26-33.
14. Yu F, Bronas UG, Konety S, Nelson NW, Dysken M, Jack C, et al. Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer’s disease: study protocol of a randomized controlled trial (The FIT-AD trial). Trials. 2014;15(1):394.
15. Agarwal M, Narayan J, Sharma P, Singh S, Tiwari S. Acute effect of uphill and downhill treadmill walk on cardiovascular response and perceived exertion in young sedentary individual. Int J Med Sci Public Health. 2017;6(7):1133-9.
16. Zhao H, Cheng L, Du X, Hou Y, Liu Y, Cui Z, et al. Transplantation of cerebral dopamine neurotrophic factor transducted BMSCs in contusion spinal cord injury of rats: promotion of nerve regeneration by alleviating neuroinflammation. Mol. Neurobiol. 2016;53(1):187-99.
17. Udeochu JC, Shea JM, Villeda SA. Microglia communication: Parallels between aging and Alzheimer's disease. Clin Exp Neuroimmunol. 2016;7(2):114-25.
18. Pyrzanowska J, Piechal A, Blecharz-Klin K, Joniec-Maciejak I, Graikou K, Chinou I, et al. Long-term administration of Greek Royal Jelly improves spatial memory and influences the concentration of brain neurotransmitters in naturally aged Wistar male rats. J Ethnopharmacol. 2014;155(1):343-51.
19. Chen D, Liu F, Wan J-B, Lai C-Q, Shen L-r. Effect of major royal jelly proteins on spatial memory in aged rats: Metabolomics analysis in urine. J Agr Food Chem. 2017;65(15):3151-9.
20. Tapia‐Rojas C, Aranguiz F, Varela‐Nallar L, Inestrosa NC. Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of A lzheimer's Disease. Brain Pathol. 2016;26(1):62-74.
21. Rammes G, Mattusch C, Wulff M, Seeser F, Kreuzer M, Zhu K, et al. Involvement of GluN2B subunit containing N-methyl-d-aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aβ) in murine models of Alzheimer's disease (AD). Neuropharmacology. 2017;123:100-105.
22. O'dell SJ, Galvez BA, Ball AJ, Marshall JF. Running wheel exercise ameliorates methamphetamine‐induced damage to dopamine and serotonin terminals. Synapse. 2012;66 (1):71-80.
23. Melancon MO, Lorrain D, Dionne IJ. Exercise increases tryptophan availability to the brain in older men age 57-70 years. Med Sci Sports Exerc. 2012;44 (5).
24. Chavanelle V, Sirvent P, Ennequin G, Caillaud K, Montaurier C, Morio B, et al. Comparison of oxygen consumption in rats during uphill (concentric) and downhill (eccentric) treadmill exercise tests. J Sport Sci Med. 2014;13(3):689.
25. Jeon YK, Ha CH. The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents. Environ Health Prev Med. 2017;22(1):27.
Journal of Nutrition,Fasting and Health
Volume 9, Issue 2
June 2021
Pages 131-136

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History

  • Receive Date: 05 July 2020
  • Revise Date: 10 August 2020
  • Accept Date: 06 September 2020

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