The Effect of Ramadan Fasting on Thyroid Hormones in 9‐13 Years Old Pre‐menarche Girls

Document Type: Research Paper

Authors

1 Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

3 Biochemistry and Nutrition, Endoscopic & Minimally Invasive Surgery, and Cancer Research Centers, Department of Nutrition, Mashhad Medical School, Mashhad University of Medical Science, Iran

4 Nutrition and Biochemistry Research Center and Department of Nutrition, Mashhad Medical School, Mashhad University of Medical Science, Iran

5 Addiction Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

6 Department of Statistic, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction: Muslims fast from dawn to dusk during Ramadan. The effects of prolonged food deprivation on endocrine hormones have been studied in healthy adults but no previous study has investigated this effect on children. This study aimed to evaluate the feasible changes in serum level of thyroxin (T3), tetraiodothyronin (T4), thyroid stimulating hormone (TSH) and body composition in pre-menarche girls. Methods: This cohort study was performed through Ramadan 2012. We enrolled fifty-eight 9-13years old girls (weight 34.20±7.96 kg, height 142.01±7.76 cm) in two groups from (31  and 27 in fasted and non-fasted groups, respectively) prior to Ramadan until afterwards. Weight and height of the subjects were measured using standard methods, and then Body Mass Index (BMI) was calculated.  Body composition was measured using Bio Impedance Analyzer (BIA) method.  Serum concentrations of T3, T4 and TSH hormones were measured by Radio Immunoassay (RIA). Paired t-test was used to compare result of each group before and after Ramadan. Independent t-test was used to compare two groups together. Tanner intervention variable was controlled by generalized linear models intervening test. SPSS.11 software was used for data analysis. Results: Ramadan fasting induces a significant decrease in BMI and weight on fasted group (p=0.005, p=0.044, respectively) while a significant increase was observed in non-fasted group (p<0.001). Although, T3 decreased significantly by fasting (p<0.001), it remained in the normal range. Hence, T4 decreased and TSH increased slightly in both groups. Conclusions: According to our findings, despite a significant reduction of T3 in fasting group, variation in thyroid hormones level remained in the normal range during Ramadan fasting.

Keywords


Azizi F. Medical aspects of Islamic fasting.
- Mesbahzadeh B, Ghiravani Z, Mehrjoofard H Effect of Ramadan fasting on secretion of sex hormones in healthy single males.
muazzam G, Arthur H Ramadan fasting and medical science.
Azizi F Islamic Fasting and Health.
Ahmadinejad Z, Ziaee V, Rezaee M, Yarmohammadi L, Shaikh H, Bozorgi F, et al The effect of ramadanfasting on thyroid hormone profile: A cohort study.
Rogol AD Sex steroids, growth hormone, leptin and the pubertal growth spurt.
Radicioni A, Tahani N, Spaziani M, Anzuini A, Piccheri C, Semeraro A, et al Reference ranges for thyroid hormones in normal Italian children and adolescents and overweight adolescents.
Athar,S and M. Habib managment of stable type 2 diabetes mellitus NIDDM during Islamic fasting in Ramadan.
Hussein,R., M.T. Duncan and S.L Chang. Effects of fasting in Ramadan on tropical AsiaticMoslems.
Frost,G.and S.Pirani meal frequency and nutritional intake during Ramadan : A pilot study.
Ati J el, Beji C, Danguir J Increased fat oxidation during Ramadan fasting in healthy women: an adaptative mechanism for body-weight maintenance..
MMG Mauzzam Ramadan Fasting and Medical Science.
Ünalacak M, Kara İH, Baltaci D, Erdem Ö, Bucaktepe PGE Effects of Ramadan fasting on biochemical and hematological parameters and cytokines in healthy and obese individuals.
Bouhlel E, Denguezli M, Zaouali M, Tabka Z, Shephard RJ Ramadan fasting's effect on plasma leptin, adiponectin concentrations, and body composition in trained young men.
Coiro V, Volpi L, Caffarri G, Colla R, Chiodera P Effects of pyridostigmine and naloxane on the abnormal TSH response to TRH during starvation in humans.
Bogdan A, Bouchareb B, Touitou Y Ramadan fasting alters endocrine and neuroendocrine circadian patterns. Meal-time as a synchronizer in humans?.
Sajid KM,Akhtar M,Malik GQ Ramadan fasting and thyroid hormone profile.
Azizi F Effect of dietary composition on fasting induced changes in serum thyroid hormones and thyrotropin.
Spencer CA, Lum SM, Wilber JF, Kapten EM, Nicoloff JT Dynamics of serum thyrotropin and thyroid hormone changes in fasting.
Chan JL, Heist K, DePaoli AM, Veldhuis JD, Mantzoros CS The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.
Borst GC, Osburne Rc, O’brian Jt, Georges Lp, Burman Kd Fasting Decreases Thyrotropin Responsiveness to Thyrotropin-Releasing Hormone: A Potential Cause of Misinterpretation of Thyroid Function Tests in the Critically III.
anthony s.fauci dlk lj, eugene braun walel, stephan l. hauser, joseph loscalzo Principles of Harrison’s internal medicine.
robert M. kliegman bFs nFs, beherman Nelson text book of pediatrics.
john E. hall g guyton and hall text book of medical physiology.
Azizi, F, Nafarabadi M and Amini M Serum thyroid hormone and thyrotropin concentration during ramadan in healthy women.
Sulimani RA The effects of Ramadan fasting on thyroid functions in healthy male subjects.
Suryanarayana BV, Kent JR, Meister L, Parlow AF Pituitary‐‐gonadal axis during prolonged total starvation in obese men.