The Effects of Eight Weeks of Rhythmic Exercises with Music on IGFBP-3 Levels, Insulin Resistance Index and Quality Of Life in Women with Different Body Mass Indices

Document Type : Research Paper

Authors

1 MSc in Sport Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran

2 Assistant Professor in Sport Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran

3 Associate Professor in Sport Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran

Abstract

Introduction: Inactivity and passive lifestyle have led to an increase in mortality and the incidence of chronic diseases such as hypertension, type 2 diabetes and obesity. The aim of this study was to investigate the effects of eight weeks of rhythmic exercises with music on IGFBP-3, insulin resistance index and quality of life in women with different body mass indices. Methods: In this quasi-experimental study, 33 sedentary women were randomly divided into three groups: exercise + normal body mass index (20 to 24.9 kg/m²) (n= 11), exercise + overweight body mass index (25 to 29.9 kg/m²) (n=11), and exercise + obese body mass index (30 to 34.9 kg/m²) (n=11). The rhythmic exercise program consisted of 8 weeks, three sessions per week and each session was performed for 45 to 60 minutes with an intensity equal to 60 to 70% HRmax. The paired t-test and one-way ANOVA with repeated measures were used to compare changes within and between groups. Results: The results show that the time interaction in the groups in terms of IGFBP-3, insulin, glucose, insulin resistance and quality of life is not statistically significant. The results of the comparison of within-group means show that in the normal body mass index group, the overweight and obese groups, IGFBP-3 levels, quality of life have significantly increased. In the overweight and obese body mass index groups, serum insulin levels, glucose, and insulin resistance index have significantly decreased. Conclusion(s): Rhythmic exercise increased IGFBP-3 concentration and decreased fasting glucose, fasting insulin, insulin resistance index in all three groups.

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  1. Djalalinia S, Saeedi Moghaddam S, Sheidaei A, Rezaei N, Naghibi Iravani SS, Modirian M, et al. Patterns of obesity and overweight in the iranian population: findings of steps 2016. Front Endocrinol (Lausanne). 2020;11:42.
  2. Nomatshila SC, Mabunda SA, Puoane T, Apalata TR. Prevalence of Obesity and Associated Risk Factors among Children and Adolescents in the Eastern Cape Province. Int J Environ Res Public Health. 2022;19(5).
  3. Marsh ML, Oliveira MN, Vieira-Potter VJ. Adipocyte metabolism and health after the menopause: The role of exercise. Nutrients. 2023;15(2):444.
  4. Kim HS. Role of insulin-like growth factor binding protein-3 in glucose and lipid metabolism. Ann Pediatr Endocrinol Metab. 2013;18(1):9-12.
  5. Chan SS, Schedlich LJ, Twigg SM, Baxter RC. Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3. American Journal of Physiology-Endocrinology and Metabolism. 2009;296(4):E654-E63.
  6. Mahindru A, Patil P, Agrawal V. Role of Physical Activity on Mental Health and Well-Being: A Review. Cureus. 2023;15(1):e33475.
  7. Herbert C, Meixner F, Wiebking C, Gilg V. Regular Physical Activity, Short-Term Exercise, Mental Health, and Well-Being Among University Students: The Results of an Online and a Laboratory Study. Front Psychol. 2020;11:509.
  8. Ben S, Timothy O, Rachel C, Dorothea D, Rosa V, Amanda W, et al. Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews. Br J Sports Med. 2023;57(18):1203.
  9. Chavarrias M, Villafaina S, Lavín-Pérez AM, Carlos-Vivas J, Merellano-Navarro E, Pérez-Gómez J. Zumba®, fat mass and maximum oxygen consumption: A systematic review and meta-analysis. Int J Environ Res Public Health. 2021;18(1):105.
  10. Yamasaki J, Sakisaka K, Mission PA, Soluta NG, delos Santos NJV, Palaca JV, et al. Factors Associated with Regular Zumba Practice as Preliminary Results: A Population-Based Approach in Cebu Province, the Philippines. Int J Environ Res Public Health. 2021;18(10):5339.
  11. Barranco-Ruiz Y, Ramírez-Vélez R, Martínez-Amat A, Villa-González E. Effect of two choreographed fitness group-workouts on the body composition, cardiovascular and metabolic health of sedentary female workers. Int J Environ Res Public Health. 2019;16(24):4986.
  12. Barranco-Ruiz Y, Villa-González E. Health-related physical fitness benefits in sedentary women employees after an exercise intervention with Zumba Fitness®. Int J Environ Res Public Health. 2020;17(8):2632.
  13. Mohammadi A, Bijeh N, Moazzami M, khodaei K, Rahimi N. Effect of exercise training on spexin level, appetite, lipid accumulation product, visceral adiposity index, and body composition in adults with type 2 diabetes. Biol Res Nurs. 2022;24(2):152-62.
  14. Ljubojevic A, Jakovljevic V, Bijelic S, Sârbu I, Tohănean DI, Albină C, et al. The Effects of Zumba Fitness(®) on Respiratory Function and Body Composition Parameters: An Eight-Week Intervention in Healthy Inactive Women. Int J Environ Res Public Health. 2022;20(1).
  15. Nishida Y, Matsubara T, Tobina T, Shindo M, Tokuyama K, Tanaka K, et al. Effect of low-intensity aerobic exercise on insulin-like growth factor-I and insulin-like growth factor-binding proteins in healthy men. Int J Endocrinol. 2010;2010.
  16. Azadi B, BolBoli L, Khani M, Siyahkohyan M, Pourrahim A. Comparison of the Effect of Eight Weeks of Continuous and High Intensity Interval Training on GH/IGF-1 Serum Indices and Aerobic performance of Active Young Males. Journal of Sport Biosciences. 2022;14(1):101-18.
  17. Biadgo B, Tamir W, Ambachew S. Insulin-like Growth Factor and its Therapeutic Potential for Diabetes Complications - Mechanisms and Metabolic Links: A Review. Rev Diabet Stud. 2020;16(1):24-34.
  18. Kim M, Kim EY, Kim EY, So CH, Kim CJ. Investigating whether serum IGF-1 and IGFBP-3 levels reflect the height outcome in prepubertal children upon rhGH therapy: LG growth study database. PLoS One. 2021;16(11):e0259287.
  19. Kim T, Chang JS, Kim H, Lee KH, Kong ID. Intense Walking Exercise Affects Serum IGF-1 and IGFBP3. Journal of lifestyle medicine. 2015;5(1):21-5.
  20. Jiang Q, Lou K, Hou L, Lu Y, Sun L, Tan SC, et al. The effect of resistance training on serum insulin-like growth factor 1 (IGF-1): a systematic review and meta-analysis. Complement Ther Med. 2020;50:102360.
  21. Bacon SL, Sherwood A, Hinderliter A, Blumenthal JA. Effects of exercise, diet and weight loss on high blood pressure. Sports Med. 2004;34:307-16.
  22. Sabag A, Chang D, Johnson NA. Growth hormone as a potential mediator of aerobic exercise-induced reductions in visceral adipose tissue. Front Physiol. 2021;12:623570.
  23. Varma Shrivastav S, Bhardwaj A, Pathak KA, Shrivastav A. Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): Unraveling the Role in Mediating IGF-Independent Effects Within the Cell. Frontiers in cell and developmental biology. 2020;8:286.
  24. Forbes BE, McCarthy P, Norton RS. Insulin-like growth factor binding proteins: a structural perspective. Front Endocrinol (Lausanne). 2012;3:38.
  25. Weng X, Wang C, Yuan Y, Wang Z, Kuang J, Yan X, et al. Effect of Cold Exposure and Exercise on Insulin Sensitivity and Serum Free Fatty Acids in Obese Rats. Med Sci Sports Exerc. 2023.
  26. Haldrup D, Wei C, Holland-Fischer P, Kristensen K, Rittig S, Lange A, et al. Effects of lifestyle intervention on IGF-1, IGFBP-3, and insulin resistance in children with obesity with or without metabolic-associated fatty liver disease. Eur J Pediatr. 2023;182(2):855-65.
  27. Fairey AS, Courneya KS, Field CJ, Bell GJ, Jones LW, Mackey JR. Effects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: a randomized controlled trial. Cancer Epidemiology Biomarkers & Prevention. 2003;12(8):721-7.
  28. Hulett NA, Scalzo RL, Reusch JEB. Glucose Uptake by Skeletal Muscle within the Contexts of Type 2 Diabetes and Exercise: An Integrated Approach. Nutrients. 2022;14(3).
  29. Zhao X, An X, Yang C, Sun W, Ji H, Lian F. The crucial role and mechanism of insulin resistance in metabolic disease. Front Endocrinol (Lausanne). 2023;14:1149239.

Articles in Press, Accepted Manuscript
Available Online from 06 March 2024
  • Receive Date: 03 February 2024
  • Revise Date: 28 February 2024
  • Accept Date: 06 March 2024