The Effects of Aerobic Exercise on the Levels of Leptin and Adiponectin in Overweight Women

Document Type: Research Paper

Authors

1 Department of Sport Physiology, Faculty of Physical Education and Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran

2 Department of General Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Intoduction: Several epidemiological studies have indicated factors such as Leptin level, Adiponectin and plasma adiponectin-to-leptin index to be the predicting biomarkers for cardiovascular diseases. Given the importance of healthy nutrition and adequate exercise in reducing the risk of Atherosclerosis, this study aimed to investigate the effects of fasting and aerobic exercise on the level of leptin and adiponectin in overweight women. Methods: In this study, 27 overweight and obese women with the body mass index (BMI) of ≥25 kg/m2 and the age range of 45-20 years were selected by targeted sampling and were divided into two groups of fasting accompanied with aerobic exercise (N=15), and fasting only (N=12). The active group had an exercise protocol including three 60-minute sessions of aerobic exercise per week, with the maximum heart rate of 50-65%. Anthropometric dimensions and blood levels of leptin and adiponectin were measured in all the subjects before, at the second week and the fourth week and one week after Ramadan. Data analysis was carried out using repeated measures, and a P value of ≤0.05 was considered significant. Results: In this study, one month of fasting accompanied with aerobic exercise had a significant effect on the amount of leptin, adiponectin and leptin-to-adiponectin ratio (P<0.05). However, no significant differences were observed between the two study protocols in terms of changes in leptin, adiponectin and leptin-to-adiponectin ratio in the two study groups. Conclusion: According to the results of this study, aerobic exercise during Ramadan could not result in any significant changes in the level of leptin, adiponectin and adiponectin-to-leptin index in comparison to fasting alone. The insignificant differences in the changes of leptin and adiponectin indices between the two study protocols could be due to the insufficient number of aerobic exercise sessions, as well as the low intensity and duration of the exercises.  

Keywords


  1. Brown WV, Fujioka K, Wilson PW, Woodworth KA. Obesity: why be concerned?. Am J Med 2009; 122 Suppl 1:S4-11
  2. Sharifi F, Anjom Shoa A, Izadfar F, Mazloomzadeh S.  Evaluation of Islamic fasting on the serum level of Adiponectin and CRP هn patients with metabolic syndrome of Zanjan city. Iranian Journal of Diabetes and Lipid 2010;10(2):214-220.
  3. Vendrell J, Broch M, Vilarrasa N, Molina A, Manuel Gómez J, Gutiérrez C, et al. Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: Relationships in Obesity. Nature 2004; 12, 962–971.
  4. Larijani B, Moghadas M. Leptin newfound hormone on adipose tissue and its effects on obesity. Iranian Journal of Diabetes and Lipid 2001;4(3);1-10.
  5. Afkhami M, Sedghi H. Diabetes and obesity: the most common metabolic disorders in the world. Journal of shahid Sadoughi of Yazd university of Medical Sciences 2002;10(4):7-19.
  6. Saad M, Riad-Gabriel M, Khan A, Sharma A, Michael R, et al. Diurnal and ultradian rhythmicity of plasma leptin: effects of gender and adiposity. J Clin Endocrinol Metab 1998; 83:453-459.
  7. Weigle D, Cummings D, Newby P, Breen P, Frayo R, et al. Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet. J Clin Endocrinol Metab 2003; 88: 1577-1586.
  8. Goldstein B, Scalia R, Ma X. Protective vascular and myocardial effects of adiponecti. Nat Clin Pract Cardiovasc  2009; 6(1):27-35.
  9. Giahi L, Jazayeri A, Rahimi A, Rahmani M, Larijani B. Evaluation of relationship between serum adiponectin levels and percent of body mass with insulin sensitivity in overweight men. Journal of Diabetes and Lipid of 2006;6(2);188-183.
  10. Ouchi K, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, et al. Aliponectin, adipocyte drived plasma protein, inhibits endothelial NFKB signaling through cAMP-dependent pathway. Circulation 2000; 102: 1296-130.
  11. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsomoto S, Ouchi N, et al. Association of  hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003; 23: 85-9.
  12. Yang B, Chen L, Qian Y, Triantafillou J, McNulty J, Carrick K, et al. Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats. Biochem Biophys Res Commun 2006; 341: 209-17.
  13. Maestu J, Jurimae J, Valter I, Jurimae T. Increases in ghrelin and decreases in leptin without altering adiponectin during weight loss in male competitive bodybuilders. Metabolism 2008; 57: 221-5.
  14. Madsen E, Rissanen A, Bruun JM, Skogstrand K, Tonstad S, Hougaard DM, et al. Weight loss larger than10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3- year weight loss study. Eur J Endocrinol 2008; 158: 179-87.
  15. Lilja M, Rolandsson O, Norberg M, Soderberg S. The impact of leptin and adiponectin on incident type 2 diabetes is modified by sex and insulin resistance. Metab Syndr Relat Disord 2012, 10:143–151.
  16. Al-Hamodi Z, AL-Habori M, Al-Meeri A, Saif-Ali R. Association of adipokines, leptin/adiponectin ratio and C-reactive protein with obesity and type 2 diabetes mellitus. Diabetology & Metabolic Syndrome 2014, 6:99.
  17. Tajtakova M, Petrasova D, Pidanicova A, Gallovicova A, Blanarova C, Petrovicova J. Serum levels of leptin, adiponectin, retinol binding protein4 and leptin/adiponectin molar ratio as another possible marker of insulin resistance in obese. Bratisl Lek Listy 2010; 111:212–215.
  18. Thorand B, Zierer A, Baumert J, Meisinger C, Herder C, Koenig W. Associations between leptin and the leptin/adiponectin ratio and incident type 2 diabetes in middle-aged men and women: results from the MONICA/KORA Augsburg Study 1984–2002. Diabetic Med 2010, 27:1004–1011.
  19. Izadi V, Azadbakht L. The relationship between dietary patterns, weight loss regimes, food components and plasma adiponectin levels. Journal of Isfahan medical faculty 2012;199:1131-1144.
  20. Larijani B, Zahedi F, Sanjari M, Amini M.R, Jalili R.B, Adibi H, et al. The effect of Ramadan fasting on fasting serum glucose in healthy adults. The Medical Journal of Malaysia 2003, 58: 678–680
  21. .AL-Hourani H.M, Atoum M.F, Akel S.C, Hijjawi N.D, Awawdeh S.Effects of ramadan fasting on some haematological and biochemical parameters. Jordan Journal of Biological Sciences 2009; 2(3):103-108
  22. .Adlouni A, Ghalim N, Saile R, Had N, Parra HJ, Benslimance A. Beneficial effect on serum apo AI, apo B and Lp AI levels of Ramadan fasting. Clinica Chimica Acta 1998; 271:179-189
  23. .Lotfi S, Madani M, Abassi A, Tazi A, Boumahmaza M,Talbi M. CNS activation, reaction time, blood pressure and heart rate variation during ramadan intermittent fasting and exercise. World Journal of Sport Sciences 2010; 3(1): 37-43
  24. .AL-Hourani H.M, Atoum M.F, Akel S.C, Hijjawi N.D, Awawdeh S.Effects of ramadan fasting on some haematological and biochemical parameters. Jordan Journal of Biological Sciences 2009; 2(3):103-108
  25. .Kamal Mohmoud Saleh Mansi. Study the Effects of Ramadan Fasting on the Serum Glucose and Lipid Profile among Healthy Jordanian Students. American Journal of Applied Sciences 2007; 4 (8): 565-569
  26. .Haghdoost, A.A and PoorRanjbar, M. The interaction between physical activity and fasting on the serum lipid profile during Ramadan. Singapore Med J 2009; 50(9):897-906
  27. .Tayebi, Hanachi, Ghanbari Niaki, Nazar Ali, Ghorbanalizadeh. Ramadan Fasting and Weight-Lifting Training on Vascular Volumes and Hematological Profiles in Young Male Weight-Lifters. Global Journal of Health Science 2010; 2(1): 161-166
  28. .Ramadan J. Does Fasting during Ramadan Alter Body Composition, Blood Constituents and Physical Performance? Med Principles Pract 2002; 11(suppl 2):41-46
  29. .Yousef Boobes, Bassam Bernieh, M. Raafat Al Hakim. Fasting Ramadan in Kidney Transplant Patients is Safe. Saudi J Kidney Dis Transpl 2009; 20(2):198-200.
  30. Maislos M, Khamaysi N, Assali A, Abu-Rabiah Y, Zvili I, Shany S. Marked increase in plasma high density lipoprotein cholesterol after prolonged fasting during Ramadan. Am J Clin Nutr 1993; 57: 640 –642.
  31. Ravishankar RM, Malathi R. Possible correlation  of leptin with body fat distribution and adiposity: Evaluation of serum leptin in South Indian population. Reprod Med Biol 2007; 6: 117-125.
  32. Dubuc GR, Phinney SD, Stern JS, Havel PJ. Changes of serum leptin and endocrine and metabolic parameters after 7 days of energy restriction in men and women .Metabolism 1998; 47(4):429-34.
  33. Hosni Nosrat Z. The effect of fasting combined with aerobic physical activity on health-related physical fitness, insulin and leptin plasma. MA thesis 2012. University of Kurdistan.
  34. Ranjbar R, Ahmadizad S, Khoshniat Nikoo M, Mohsenzadeh A. The effect of endurance training and a lack of exercise coupled with fasting on serum leptin and fructosamine of overweight men. Journal of Endocrinology and Metabolism 2013;15(3):269-278.
  35. Kassab S, Abdul-Ghaffar T, Nagalla DS, Sachdeva U, Nayar U. Interactions between leptin, neuropeptide-Y and insulin with chronic diurnal fasting during Ramadan. Ann Saudi Med. 2004;24(5):345-9.
  36. Khalili S, Noori R. The effect of 8 weeks resistance training on leptin and insulin resistance index in obese girls.journal of Hamedan university of medical sciences 2013;20(1): 29-65.
  37. Zarghami N, Maleki MJ, Mohammadzadeh Gh, Mamaghani F, Pourhasan M. Relationship between changes in serum leptin levels and lipid profile with anthropometric indices in women with different degrees of obesity. Journal of Zanjan university of medical sciences 2010;18(72):13-24
  38. Ogier V, Ziegler O, Mejean L, Nicolas J. Obesity  is associated with decreasing levels of the circulating soluble leptin receptor in humans. Inter J  Obes Relat Metab Disord 2002; 26: 496-503.
  39. Ryan AS, Nicklas BJ, Berman DM, Elahi D. Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women. Int J Obes Relat Metab Disord. 2003 Sep;27(9):1066-71.
  40. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Artioscler Thromb Vasc Biol 2000; 20: 1595–1599.
  41. Bouhlel E, Denguezli M, Zaouali M, Tabka Z, Shephard RJ. Ramadan Fasting’s Effect on Plasma Leptin, Adiponectin Concentrations, and Body Composition in Trained Young Men. Int J Sport Nutr Exerc Metab. 2008;18(6):617-27.
  42. Mazzali, G., Di Francesco, V., Zoico, E., Fantin, F., Zamboni, G., Benati, C., et al. Interrelations between fat distribution, muscle lipid content, adipocytokines, and insLIN lin resistance: Effect of moderate weight loss in older women. The American Journal of Clinical Nutrition 2006; 84:1193–1199.