The Positive Role of Probiotics in Controlling and Treating Gestational Diabetes in Pregnancy

Articles in Press

Document Type : Review Article

Authors

1 Department of Obestetrics & Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Student of Specialist, Department of Radiology, Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

3 Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: Diabetes, including gestational diabetes mellitus (GDM), has a high global prevalence and remains a significant public health concern. The pathophysiology of GDM involves carbohydrate intolerance and can have substantial effects on pregnancy outcomes. Probiotics—naturally occurring microorganisms in the human gut—have been suggested to confer health benefits. Inflammatory processes play a central role in the development of GDM, and probiotics may influence immune system function and modulation. This study aims to explore the potential role of probiotics as a therapeutic intervention for GDM through a comprehensive review of the literature published between 2010 and 2024. Key search terms included: "probiotics," "symbiosis," "Bifidobacterium," "Lactobacillus," "gestational diabetes," "infantile consequences," and "metabolic profile." Only studies involving human subjects were included in this review. Methods: A comprehensive review of literature from 2010 to 2024 was conducted to clarify the role of probiotics as a treatment for GDM. Key search terms included "probiotics," "symbiosis," "bifidobacterium," "Lactobacillus," "Gestational diabetes," "Infantile consequences," and "Metabolic profile." This research includes human articles. Results: Although the evidence is limited, probiotics have a positive effect on blood glucose levels and reduce insulin resistance, making them potentially effective in treating GDM. Conducting more studies on different types of probiotics and in larger patient populations can provide further insights into this issue.

Keywords

Main Subjects

References

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Journal of Nutrition,Fasting and Health

Articles in Press, Accepted Manuscript
Available Online from 15 July 2025

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History

  • Receive Date: 19 May 2025
  • Revise Date: 13 July 2025
  • Accept Date: 15 July 2025

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