The Effect of Resveratrol with Interval Training On Oxidative Stress Biomarkers and Liver Enzymes in Men with Non-Alcoholic Fatty Liver Disease

Articles in Press

Document Type : Research Paper

Authors

Department of Physical Education, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.

Abstract

Introduction: as esveratrol and exercise can influence the oxidative stress processes in non-alcoholic fatty liver disease (NAFLD), present research aimed to reviwe the effects of  of interval training combined with resveratrol supplementation on liver enzymes, total antioxidant capacity (TAC) and malondialdehyde (MDA), in individuals with NAFLD. Methods: 48 participants randomly assigned into four groups of 12 persons including 1) resveratrol, 2) training, 3) training + resveratrol and 4) placebo groups. The exercise sessions were conducted over eight weeks, three times per week. Both the supplement and the training with supplement groups received 400 mg capsule daily for eight weeks. The placebo group recived a 400 mg starch capsule as a placebo daily for the same duration. Liver enzymes (ALT, AST), TAC and MDA levels were assessed at the pre- test and post- test. Two- way ANOVA and paired sample t tests were used for statistical analysis of dat (P≤0.05). Results: Resveratrol significantly increased TAC (P=0.002) and decreased ALT (P=0.01) as well as ALT reduced by training (P=0.001). Conclusion: It appears that resveratrol and training alone can improved NAFLD implication by improving liver enzyme, nevertheless they have no synergistic effects.

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Main Subjects

References

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Journal of Nutrition,Fasting and Health

Articles in Press, Accepted Manuscript
Available Online from 06 June 2026

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History

  • Receive Date: 09 October 2025
  • Revise Date: 03 June 2026
  • Accept Date: 06 June 2026

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