The effect of Ramadan Fasting on Biochemical Substances Relating to the Renal and Bone Function of Fasting Pregnant Women, 2011-2012

Document Type : Research Paper


1 Department of Pediatrics, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

2 Department of Epidemiology and Biostatistics, Faculty of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran

3 Department of Internal Medicine, Faculty of Medicine, Shaharekord University of Medical Sciences, Shahrekord, Iran

4 Department of Epidemiology and Biostatistics, Faculty of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran


Introduction: The effect of fluid and food restrictions on biochemical substances relating to the renal and bone function of pregnant women is not well defined. The purpose of this study is to evaluate the effects of fluid and food restriction on the following substances in pregnant fasting women during Ramadan: blood urea nitrogen (BUN), creatinine (Cr), calcium (Ca), phosphorus (P), and alkaline phosphates (ALP). Methods: Thirty fasting pregnant women voluntarily participated in this prospective descriptive study. The serum levels of BUN, Cr, P, and ALP were measured  at the baseline, and on the 7th, 14th, and 28th days of Ramadan; the measurements were also performed 2 weeks after this month. The statistical significance was defined as PResults: As to the results of the present study,the weight and body mass index (BMI) of women didn’t change during the experiment. BUN and Cr increased significantly by the 2nd week of Ramadan; however, no differences were observed between BUN and Cr values at the end of Ramadan and two weeks after it (P> 0.05); also, Cr didn’t change during Ramadan and 2 weeks after it (P> 0.05). Moreover, no differences in P and ALP levels were noticed between the end of Ramadan and two weeks after it (P> 0.05). Conclusion: According to this study, there is no sufficient evidence regarding the adverse effects of Ramadan fasting on biochemical substances relating to the renal and bone function of pregnant fasting women.


  1. Joosoph J, Abu J, Yu SL. A Survey of fasting during pregnancy Singapore Med J 2004; 45 (12) : 583 - 6.
  2. Ziaee V, Razaei M, Ahmadinejad Z, et al. The changes of metabolic profile and weight during Ramadan fasting. Singapore med J 2006; 47(5): 405- 14.
  3. Rahman M, Rashid M, Basher S, et al. Improved Serum HDL, Cholesterol Profile among Bangladeshi male student during Ramadan fasting. East Mediterr Health J 2004; 10 (1-2): 131-7.
  4. Khoshdel A, Najafi M, kheiri S, et al. impact of maternal Ramadan fasting on growth parameters in exclusively breast – fed infants. Iran J Pediatr 2007; 17(4): 345- 72.
  5. Salleh H Ramadan fasting among pregnant woman in Mur distric , Malaysia and its association to health out comes. Malays J Repod Health 1989; 7(1) 69- 83.
  6. Mittenclorof R, Williams MA, Berkey CS, Celter PF. The length of uncomplicated human gestation. Obstet Gyncol 1990; 75: 929-32.  
  7. Raman L, Rajalakshmik, Krishnamachari KA, Sastry JG. Effect of calcium supplementation on under nourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nut 1978; 31: 466-469.
  8. Mayne P. Calcium phosphate and magnesium metabolism in: Clinical chemistry in Diagnosis and treatment ELSB, 6th ed. Bath press CO: UK, Great Britain; 1996. P. 179- 188, 144.
  9. Tran HA. Biochemical test in pregnancy. Aust prescr 2005; 28: 98-101, 2005, Cited by: Dunlop W and Davidson JM. “Renal haemodyanic and tubular function in human pregnancy clinical obst Gyecol 2005; 1: 769.
  10. Khastgir G. Pregnancy associated osteoporosis. Br J obstet Gynaecol 1994; 101: 836-838.
  11. Robertson EG, Cheyne GA. Plasma biochemistry in relation to oedema of pregnancy. Br J Obestet Gynaecol 1972; 79:769-73.
  12. Kuhlback B , Widholm O. plasma creatinine in normal pregnancy. scand lab invest 1966; 18: 654-6 .
  13. Reitz RE, Doane TA, Woods JR, Weinstein RC. Calcium, mangnesium, phosphorus and parathyroid Hormone interrelationship in pregnancy and newborn infants, obstet Gynecol 1977; 50: 701-4.
  14. Pitkin RM, Calcium metabolism in pregnancy: A review. Am J obstet Gyneeol 1975; 121: 724-37.
  15. Gharbi M, Akrot M, Zouari B. Food intake during and outside Ramadan. East Mediterr Health. 2003; 9(12): 131-40.
  16. Boobes Y, Bernieh B, Al Hakim MR. Fasting Ramadan in kidney transplant patints is safe. Saudi J Kidny Dis Transpl 2009; 20 (2): 198- 200.
  17. Degoutte F, Jouanel P, Begue RJ, Colombier M, Lac G, Pequignot JM, et al. Food restriction, performance, biochemical, psychological and endocrine changes in judo athletes. Int J sport Med 2006; 27 (1) : 9- 18.
  18. Kovacs CS, El –Hajj Fulihan G. Calcium and bone disorders during pregnancy and lactation. Endocrinol Metab Clin N Am 2006; 35: 21- 51.
  19. Gharedaghi M, Ghomian N, Rahimi H, Bahari M, Ariamanesh Ash. Serum calcium, phosphorous and alkaline phosphatase level in different trimester of pregnancy. J Mashhad Uni med sci 2007 101-106.
  20. Hosking DJ. Calcium homeostasis in pregnancy. Clin Endocrinol 1996; 45 (1): 1-6.
  21. Power MI, Heamey RP, Kalkwarf HY, Power ML, Heaney RP, Kalwarf HJ, et al. the role of calcium in healthand disease. Am J obstet Gnecol 1999; 181 (6): 1560.