Journal of Nutrition,Fasting and Health

Journal of Nutrition,Fasting and Health

Interactive Effects of Continuous and Interval Training with Crocin Consumption on Interleukin 17 and 18 in the Soleus Muscle of Type 2 Diabetic Rats

Document Type : Research Paper

Authors
Najimeh Moghadas
Ali Khajehlandi
Amin Mohammadi
Department of Physical Education and Sport Sciences, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran
10.22038/jnfh.2019.40715.1200
Abstract
Introduction: Muscular inflammation and atrophy is one of the characteristics of diabetes that causes motor disability in these individuals. Studies have shown that exercise training with different intensities and the use of herbal drugs can have favorable effects on diabetes. The aim of this study was to interactive effects of continuous and interval training with crocin consumption on interleukin 17 and 18 in the Soleus Muscle of type 2 Diabetic Rats. Methods: In this experimental study, 49 adult diabetic rats were randomly assigned to seven groups, including: high intensity interval training (HIIT), low intensity continuous training (LICT), HIIT + crocin consumption, LICT + crocin consumption, crocin consumption, sham, and control. HIIT and LICT groups did training for eight weeks on rodent treadmill, respectively. Crocin groups received 25 mg/kg of daily crocin for 8 weeks peritoneally. The gene expression levels of the variables were measured using Real Time-PCR. Results: HIIT increased IL-17 and 18 in the Soleus muscle tissue (p≤0.05), but LICT does not have a significant effect on changes in IL-17 and IL-18 (p≥0.05). Crocin consumption decreased expression of IL-18 and increased IL-17 in the Soleus muscle tissue (p≤0.05), and interaction of LICT and crocin consumption was significant in increasing IL-17 and IL-18 (P≤0.05). Conclusion: HIIT seems to have inflammatory effects in the muscle tissue of type 2 diabetic rats. However, the interaction of LICT and crocin was significant in the increase of IL-17 and IL-18 in the Soleus muscle tissue of type 2 diabetes rats.
Keywords
Training
Crocin
IL-17
IL18
Diabete
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Journal of Nutrition,Fasting and Health
Volume 7, Issue 3
Summer 2019
Pages 160-167

  • Receive Date 27 May 2019
  • Revise Date 09 July 2019
  • Accept Date 14 July 2019