Effects of Ramadan Fasting on Hepatic Steatosis and Liver Volume in Individuals without Chronic Liver Conditions

Document Type : Research Paper

Authors

1 Department of Radiology, Faculty of Medicine, Van Yuzuncu Yil University, 65080, Van, Turkey.

2 Department of Radiology, Antalya Training and Research Hospital, 07100, Antalya, Turkey.

Abstract

Introduction: Ramadan fasting, especially in the summer months, provides an important opportunity to evaluate the effects of variances in eating and drinking habits on the body metabolism. Our study aimed to evaluate the effect of Ramadan fasting on liver steatosis and volume measured by Magnetic Resonance Imaging(MRI) in overweight and obese people and to reveal the effect of this period on liver function tests and blood-lipid profile. Methods: Study was conducted with 34 individuals(28 male/6 female) who did not have chronic liver or systemic disease, did not use alcohol, had a BMI≥25, and committed to keep Ramadan fast. Abdominal MRI and blood analysis were performed twice; one week before and after the Ramadan. Liver fat fractions and volumes were calculated from MRI. All data were then statistically analyzed and compared. Results:The mean age of the individuals was 44,5(19-68). Before Ramadan the weight average and the mean BMI were 86,76 kg and 30,29 respectively.Although an increase in liver fat fraction (%2.92±7.99 vs %3.44±8.11;p>0.05) and a decrease in liver volume (1555.37±316.92 vs 1546.63±339.82;p>0.05) were detected after Ramadan, it was not statistically significant. There were statistically significant positive changes in blood-lipid profile and liver function tests. Conclusion:The excess consumption of food during the evening and at night and a sedentary lifestyle may have affected the results of the present study; however, avoiding a predetermined amount of food and drinks regularly for a long time would also result in statistical changes.As such, larger, long-term studies that include participants with a BMI <25 are needed.

Keywords

References

1. Adinolfi Le, Durante Mangoni E, Zampino R, Ruggiero G. hepatitis C. Virus associated steatosis–pathogenic mechanisms and clinical implications. Aliment Pharmacol Ther. 2005;22:52-5.
2. Kinner S, Reeder SB, Yokoo T. Quantitative imaging biomarkers of NAFLD. Dig Dis Sci. 2016;61(5):1337-47.
3. Ziaee V, Razaei M, Ahmadinejad Z, Shaikh H, Yousefi R, Yarmohammadi L, et al. The changes of metabolic profile and weight during Ramadan fasting. Singapore Med J. 2006;47(5):409-14.
4. Shariatpanahi ZV, Shariatpanahi MV, Shahbazi S, Hossaini A, Abadi A. Effect of Ramadan fasting on some indices of insulin resistance and components of the metabolic syndrome in healthy male adults. Br J Nutr. 2008;100(1):147-51.
5. Rahimi H, Habibi ME, Gharavinia A, Emami MH, Baghaei A, Tavakol N. Effect of Ramadan Fasting on alanine aminotransferase (ALT) in non-alcoholic fatty liver disease (NAFLD). J Fasting Health. 2017;5(3):107-12.
6. Karlas T, Wiegand J, Berg T. Gastrointestinal complications of obesity: non-alcoholic fatty liver disease (NAFLD) and its sequelae. Best Pract Res Clin Endocrinol Metab. 2013;27(2):195-208.
7. Yoshiike N, Lwin H. Epidemiological aspects of obesity and NASH/NAFLD in Japan. Hepatol Res. 2005;33(2):77-82.
8. Culha C, Gorar S, Aral Y. Circulating Obestatin levels during Ramadan fasting in normal weight and obese subjects. J Kuwait Med Assoc. 2019;51(4):335-40.
9. Akhtaruzzaman M, Hoque N, Choudhury M, Uddin MJ, Parvin T. Effect of Ramadan fasting on serum lipid profile of Bangladeshi female volunteers. Bangladesh j med biochem. 2014;7(2):47-51.
10. Ismail WI, Haron N, editors. Effect of Ramadan fasting on serum lipid profile among healthy students in UiTM. Int Conf Biol Chemical Environ Sci; 2014.
11. Vardarli MC, Hammes HP, Vardarli I. Possible metabolic impact of Ramadan fasting in healthy men. Turk J Med Sci. 2014;44(6):1010-20.
12. Shehab A, Abdulle A, El Issa A, Al Suwaidi J, Nagelkerke N. Favorable changes in lipid profile: the effects of fasting after Ramadan. PLoS One. 2012;7(10):e47615.
13. Ibrahim NSI, Hardinsyah H, Setiawan B. Hydration status and liver function of young men before and after Ramadan fasting. Jurnal Gizi dan Pangan. 2018;13(1):33-8.
14. Nasiri J, Kheiri S, Khoshdel A, Boroujeni AJ. Effect of Ramadan fast on liver function tests. Iran J Med Sci. 2016;41(5):459.
15. McCullough AJ. The epidemiology and risk factors of NASH. In: Farrell GC, George J, Hall PdlM, McCullough AJ, editors. Fatty liver disease: NASH and related disorders. Massachusetts: Blackwell Publishing Ltd; 2005. p. 23-37.
16. Chen CH, Huang MH, Yang JC, Nien CK, Yang CC, Yeh YH, et al. Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults. J Clin Gastroenterol. 2006;40(8):745-52.
17. Ersöz G, Özgen G, Aydin A, Erensoy S, MusoÄŸlu A. Diabetes Mellituslu Hastalarda KaraciÄŸer Hastalığı. Turkiye Klinikleri J Gastroenterohepatol. 1998;9(1):22-7.
18. Assy N, Kaita K, Mymin D, Levy C, Rosser B, Minuk G. Fatty infiltration of liver in hyperlipidemic patients. Dig Dis Sci. 2000;45(10):1929-34.
19. Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology. 2009;49(1):306-17.
20. Ratziu V, Charlotte F, Heurtier A, Gombert S, Giral P, Bruckert E, et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology. 2005;128(7):1898-906.
21. Bohte AE, van Werven JR, Bipat S, Stoker J. The diagnostic accuracy of US, CT, MRI and 1 H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis. Eur Radiol. 2011;21(1):87-97.
22. Ganji A, Bahari A, Esmaeilzadeh A, Soltani M. How Good Is Trans Abdominal Ultrasound for Evaluating NAFLD in the General Population? A Cross-Sectional Study. Acta Medica Iranica. 2020:562-6.
23. Petta S, Maida M, Macaluso FS, Di Marco V, Cammà C, Cabibi D, et al. The severity of steatosis influences liver stiffness measurement in patients with nonalcoholic fatty liver disease. Hepatology. 2015;62(4):1101-10.
24. Kang B-K, Yu ES, Lee SS, Lee Y, Kim N, Sirlin CB, et al. Hepatic fat quantification: a prospective comparison of magnetic resonance spectroscopy and analysis methods for chemical-shift gradient echo magnetic resonance imaging with histologic assessment as the reference standard. Invest Radiol. 2012;47(6):368-75.
25. Roldan-Valadez E, Favila R, Martinez-Lopez M, Uribe M, Mendez-Sanchez N. Imaging techniques for assessing hepatic fat content in nonalcoholic fatty liver disease. Ann Hepatol. 2008;7(3):212-20.
26. Henninger B, Zoller H, Rauch S, Schocke M, Kannengiesser S, Zhong X, et al. Automated two-point dixon screening for the evaluation of hepatic steatosis and siderosis: comparison with R2-relaxometry and chemical shift-based sequences. Eur Radiol. 2015;25(5):1356-65.
Journal of Nutrition,Fasting and Health
Volume 9, Issue 3
September 2021
Pages 221-228

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History

  • Receive Date: 20 December 2020
  • Revise Date: 19 January 2021
  • Accept Date: 26 January 2021

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