Effects of a Healthy Diet plus Peanut Consumption on the Fasting Lipid Profile of HIV-infected Adults in Nyeri County, Kenya: A Randomized Crossover Study

Document Type : Research Paper

Authors

1 Food, Nutrition and Dietetics Department, Kenyatta University, Nairobi, Kenya.

2 Food and Nutrition Department, Murang’a University of Technology, Murang’a, Kenya.

3 Biochemistry and Biotechnology Department Kenyatta University, Nairobi, Kenya.

Abstract

Introduction: Dyslipidemia is a key modifiable cardiovascular risk factor and a major clinical feature in the patients infected with the human immunodeficiency virus (HIV) in the current era of highly active antiretroviral therapy. Peanuts could reduce the risk of cardiovascular diseases as an abundant source of fiber, α-tocopherol, copper, arginine, magnesium, folate, and resveratrol. The present study aimed to evaluate the impact of supplementing peanut and counseling in the form of a healthy diet on the fasting lipid profile of HIV-infected adults. Methods: This randomized crossover clinical trial was conducted on the eligible participants who were randomly assigned to a two-arm study. In treatment I, the participants consumed 80 grams of peanuts plus their regular diet. In treatment II, the participants were provided with nutrition counseling on a healthy diet and consumed 80 grams of peanuts. Each treatment continued for eight weeks with a six-week washout interval. Results: A 3.07% reduction was observed in the total cholesterol of the subjects receiving treatment I, while the reduction rate was 5.39% in treatment II. In addition, a 12.8% decrease was observed in the triglycerides of the subjects receiving treatment 1I, as well as a 17% reduction in treatment II. A significant increase was reported in the high-density lipoprotein cholesterol in treatments I and II, with the rate estimated at 7.38% and 5.1%, respectively. Furthermore, low-density lipoprotein cholesterol decreased by 5.56% in treatment I and 4.32% in treatment II. The estimated 10-year risk of contracting coronary heart disease reduced significantly between the baseline and end of the study (P=0.03). Conclusion: According to the results, regular consumption of peanuts could improve the fasting lipid profile of HIV-infected patients and reduce the risk of coronary heart disease.

Keywords

References

  1. Aikins AD, Boynton P, Atanga LL. Developing effective chronic disease interventions in Africa: insights from Ghana and Cameroon. Globalization and Health. 2010; 6(1):6.
  2. Lemoine M, Girard PM, Thursz M, Raguin G. In the shadow of HIV/AIDS: Forgotten diseases in sub-Saharan Africa: Global health issues and funding agency responsibilitiesJ Public Health Policy. 2012; 33(4):430-8.
  3. Maher D, Waswa L, Baisley K, Karabarinde A, Unwin N, Grosskurth H. Distribution of hyperglycaemia and related cardiovascular disease risk factors in low-income countries: a cross-sectional population-based survey in rural Uganda. Int J Epidemiol. 2011; 40(1):160-71.
  4. Effros RB, Fletcher CV, Gebo K, Halter JB, Hazzard WR, Horne FM, Huebner RE, Janoff EN, Justice AC, Kuritzkes D, Nayfield SG. Workshop on HIV infection and aging: what is known and future research directions. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2008; 47(4):542.
  5. Mocroft A, Ledergerber B, Katlama C, Kirk O, Reiss PD, Monforte AD, Knysz B, Dietrich M, Phillips AN, Lundgren JD, EuroSIDA Study Group. Decline in the AIDS and death rates in the EuroSIDA study: an observational study. The Lancet. 2003; 362(9377):22-9.
  6. Carr A, Samaras K, Burton S, Law M, Freund J, Chisholm DJ, Cooper DA. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. Aids. 1998; 12(7):F51-8.
  7. Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med. 2005 Jan 6; 352(1):48-62.
  8. Schambelan M, Benson CA, Carr A, Currier JS, Dubé MP, Gerber JG, Grinspoon SK, Grunfeld C, Kotler DP, Mulligan K, Powderly WG. Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an International AIDS Society-USA panel. J Acquir Immune Defic Syndr. 2002; 31(3):257-75.
  9. Henry K, Melroe H. Atorvastatin and gemfibrozil for protease-inhibitor-related lipid abnormalities. The Lancet. 1998; 352(9133):1031-2.
  10. Moyle GJ, Sabin CA, Cartledge J, Johnson M, Wilkins E, Churchill D, Hay P, Fakoya A, Murphy M, Scullard G, Leen C. A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy. Aids. 2006; 20(16):2043-50.
  11. Barrios A, Blanco F, García-Benayas T, Gómez-Viera JM, de la Cruz JJ, Soriano V, González-Lahoz J. Effect of dietary intervention on highly active antiretroviral therapy-related dyslipemia. Aids. 2002; 16(15):2079-81.
  12. Chow S, Shao J. Wang. Sample size calculations in clinical research.2003.
  13. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K. 2007 Guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the european society of hypertension (ESH) and of the european society of cardiology (ESC). Eur Heart J. 2007; 28(12):1462-536.
  14. Alper CM, Mattes RD. Peanut consumption improves indices of cardiovascular disease risk in healthy adults. J Am Coll Nutr. 2003; 22(2):133-41.
  15. McKiernan F, Lokko P, Kuevi A, Sales RL, Costa NM, Bressan J, Alfenas RC, Mattes RD. Effects of peanut processing on body weight and fasting plasma lipids. Br J Nutr. 2010; 104(3):418-26.
  16. Lokko P, Lartey A, Armar-Klemesu M, Mattes RD. Regular peanut consumption improves plasma lipid levels in healthy Ghanaians. Int J Food Sci Nutr. 2007 Jan 1; 58(3):190-200.
  17. Ros, E. Nuts and novel biomarkers of cardiovascular disease. Am J Clin Nutr. 2009; 89(5), 1649S-56S
  18. Djoussé L, Rudich T, Gaziano JM. Nut consumption and risk of hypertension in US male physicians. Clinical Nutrition. 2009 Feb 1; 28(1):10-4.
  19. Sabaté J, Oda K, Ros E. Nut consumption and blood lipid levels: a pooled analysis of 25 intervention trials. Archives of internal medicine. 2010; 170(9):821-7.
  20. Kris-Etherton PM, Yu-Poth S, Sabaté J, Ratcliffe HE, Zhao G, Etherton TD. Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk. The American journal of clinical nutrition. 1999; 70(3):504s-11s.
  21. Kris-Etherton PM, Hu FB, Ros E, Sabaté J. The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. J Nutr. 2008; 138(9):1746S-51S.
  22. Hu FB, Van Dam RM, Liu S. Diet and risk of type II diabetes: the role of types of fat and carbohydrate. Diabetologia. 2001; 44(7):805-17.
  23. Griel AE, Kris-Etherton PM. Tree nuts and the lipid profile: a review of clinical studies. Br J Nutr. 2006; 96(S2):S68-78.
  24. Appel LJ, Sacks FM, Carey VJ, Obarzanek E, Swain JF, Miller ER, Conlin PR, Erlinger TP, Rosner BA, Laranjo NM, Charleston J. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. Jama. 2005; 294(19):2455-64.
  25. Cullen P. Evidence that triglycerides are an independent coronary heart disease risk factor.  Am J Cardiol. 2000; 86(9):943-9.
Journal of Nutrition,Fasting and Health
Volume 9, Issue 3
September 2021
Pages 212-220

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History

  • Receive Date: 30 November 2020
  • Accept Date: 31 May 2021

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