The Study of Changes in Oxidative Stress-Cardiac Antioxidants Following the Use of Tribulus Terrestris Extract and Crocin After One Session of Exhaustive Exercise in the Heart Tissue of Elderly Male Rats

Document Type : Research Paper


1 Department of Exercise Physiology, Lamerd Branch, Islamic Azad University, Lamerd, Iran

2 Department of Exercise Physiology, Gilan-E-Gharb Branch, Islamic Azad University, Gilan-E-Gharb, Iran.


Introduction:  This study aimed to evaluate the changes in cardiac oxidative stress-antioxidants following the use of tribulus terrestris extract and crocin after exhaustive exercise in the heart tissue of elderly male rats. Methods: In this study, elderly male Wistar rats with an average weight of 300 g and an age range of 14 to 18 months were used as the statistical population. A total of 56 rats were selected as a statistical sample and randomly divided into seven groups of 8, including control, exhausting exercise, exercise + crocin dose of 50 mg, exercise + crocin dose of 100 mg, exercise + thrush dose of 100 mg, exercise + thrush dose of 200 mg, exercise + tortoises were divided into 400 mg doses. Results: The results showed that GPX concentration in training groups with doses of 50 and 100 crocin was significantly higher than in the vulnerable training group (p<0.05). In addition, GPX concentration was significantly higher in the groups with 50 and 100 doses of crocin than in the exercise groups with 100 and 200 doses of thistle (p<0.05). GPX was significantly higher in the exercise group and crocin 100 than in the exercise group and thrush 400 (p<0.01). The results also showed that SOD concentration in training groups with doses of 50 and 100 crocin was significantly higher than  in the specific exercise group (p<0.01). SOD concentration was significantly higher in the exercise groups with 50 and 100 doses of crocin than in the groups with 100 and 200 doses of thistle (p<0.05). Also, SOD was significantly higher in the exercise group and crocin 100 than in the exercise group and thrush 400 (p<0.017). Conclusion: Therefore, using of antioxidants is recommended to improve heart tissue function in the elderly.


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