Journal of Nutrition,Fasting and Health

Journal of Nutrition,Fasting and Health

The Effect of Selen plus Supplementation during Aerobic Training on Nitric Oxide and Myeloperoxidase in Women with Metabolic Syndrome

Document Type : Research Paper

Authors
Shams Valeh 1
Ali Banaeifar 2
Sajad Arshadi 3
Vali Shahedi 4
1 PHD Candidate, Department of Physical Education and Sports Sciences, South Thran Branch, Islamic Azad University, Tehran, Iran
2 Department of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran
3 Assistant Professor, Department of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran
4 Assisstant Professor, Department of Physical Education and Sports Sciences, Parand Branch, Islamic Azad University, Tehran, Iran
10.22038/jnfh.2023.71649.1438
Abstract
Introduction: Obesity and metabolic syndrome are associated with inflammation, vascular endothelial dysfunction and cardiovascular complications.In this study, the aim was to investigate the effect of aerobic training combined with Selen Plus supplementation on the serum levels of nitric oxide and myeloperoxidase in obese women with metabolic syndrome. Methods: In this quasi-experimental study, 48 obese women (30 ≤ BMI ≤ 36) with metabolic syndrome aged 30-45 years were randomly divided into 4 groups: control (no intervention); Selen Plus (1000 grams/daily); aerobic training (every other day) and combined group (aerobic training + selen plus). Fasting levels of nitric oxide and myeloperoxidase and anthropometric indices were measured before and 48 hours after the final training session in each group. ANCOVA statistical test was used to compare the data and paired t-test was used to determine intra-group changes (p < 0.05). Results: Compared to the control group, serum nitric oxide significantly increased and myeloperoxidase significantly decreased in the aerobic, selen plus and combined groups (p=0.001).Nitric oxide in the combined group increased significantly compared to selen plus group (p=0.042). Conclusion: Selen plus supplementation during aerobic training is associated with improvement of vascular endothelial function indices in women with metabolic syndrome compared to its use alone.
Keywords
Vascular endothelial
Aerobic training
Selen plus
Metabolic syndrome
  1. Alizade Z, Azadbakht L. Review of epidemiology of metabolic syndrome in Iran. Iranian Journal of Diabetes and Metabolism. 2017; 15(3): 143-57. (Persian)
  2. Abenavoli L, Scarlata GGM, Scarpellini E, Boccuto L, Spagnuolo R, Tilocca B, et al. Metabolic-dysfunction-associated fatty liver disease and gut microbiota: from fatty liver to dysmetabolic syndrome. Medicina (Kaunas). 2023; 59(3):594.
  3. Dobrowolski P, Prejbisz A, Kuryłowicz A, Baska A, Burchardt P, Chlebus K, et al. Metabolic syndrome - a new definition and management guidelines. Arch Med Sci. 2022; 18(5):1133-56.
  4. Dalvand S, Niksima SH, Meshkani R, Ghanei Gheshlagh R, Sadegh-Nejadi S, Kooti W, Parizad N, Zahednezhad H, Afrisham R. Prevalence of Metabolic Syndrome among Iranian Population: A Systematic Review and Meta-analysis. Iran J Public Health. 2017; 46(4):456-67.
  5. Uzunlulu M, Telci Caklili O, Oguz A. Association between metabolic syndrome and cancer. Ann Nutr Metab. 2016; 68(3):173-9.
  6. Hayden MR. Endothelial activation and dysfunction in metabolic syndrome, type 2 diabetes and coronavirus disease 2019. J Int Med Res. 2020; 48(7):300060520939746.
  7. Kwaifa IK, Bahari H, Yong YK, Noor SM. Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications. Biomolecules. 2020; 10(2):291.
  8. da Silva FC, de Araújo BJ, Cordeiro CS, Arruda VM, Faria BQ, Guerra JFDC, Araújo TG, Fürstenau CR. Endothelial dysfunction due to the inhibition of the synthesis of nitric oxide: Proposal and characterization of an in vitro cellular model. Front Physiol. 2022; 13: 978378.
  9. Cyr AR, Huckaby LV, Shiva SS, Zuckerbraun BS. Nitric Oxide and Endothelial Dysfunction. Crit Care Clin. 2020; 36(2):307-21.
  10. Tran N, Garcia T, Aniqa M, Ali S, Ally A, Nauli SM. Endothelial nitric oxide synthase (enos) and the cardiovascular system: in physiology and in disease states. Am J Biomed Sci Res. 2022; 15(2):153-77.
  11. Bauer V, Sotníková R. Nitric oxide--the endothelium-derived relaxing factor and its role in endothelial functions. General physiology and biophysics. 2010; 29(4):319-40.
  12. Collins T, Gray K, Bista M, Skinner M, Hardy C, Wang  H,  et    Quantifying the relationship between inhibitions of VEGF receptor 2, drug induced blood pressure elevation and hypertension. Br J Pharmacol; 2018.175(4):618-30.
  13. Scharnagl H, Kleber ME, Genser B, Kickmaier S, Renner W, Weihrauch G, et al. Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography—The LURIC study. International Journal of Cardiology, 2014; 174: 96-105.
  14. Shidfar F, Rezai KH, Hosseini SH, Haydari I. The effects of vitamin E on insulin resistance and cardiovascular diseases risk factors in metabolic syndrome. Shahid Beheshti University and Health Services Endocrine and Metabolism Research Center Journal. 2008; 10(5): 445-54. (Persian)
  15. Jalili M, Aref-Hosseini S R, Kolahi S, Ebrahimi-Mamegani M A, Sabour S. The effect of combined antioxidant supplement on serum lipids levels in female Patients with rheumatoid arthritis. Yafte. 2013; 14 (5):93-104.
  16. Safari M, Ani M, Naderi G, Asgari S. The effect of volatile essences and vitamin C on LDL tendency to its receptor for prevention of atherosclerosis. Hamadan University of Medical Sciences Journal 2001; 4: 32-6. (Persian)
  17. Aghasi M, Shidfar F, Vafa M, Haydari I, Haggani H. The effect of concurrent zincvitamin A supplement on serum lipoproteins, apo-protein A-1 and B and glycemic indices in type 1 diabetes mellitus patients. Iran Nutrition and Food Industry Journal. 2008; 3(2): 63-71. (Persian)
  18. Cerhan JR, Saag KG, Merlino LA, Mikuls TR, Criswell LA. Anti-oxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women. Am J Epidemiol. 2003; 157(4): 345-54.
  19. Ghardashi Afousi A, Gaeini A, Gholami Borujeni B. The effect of aerobic interval training on endothelial vasculature function in type 2 diabetes patient. IJRN. 2016; 2 (3):27-39.
  20. Shemshahi A, Askari Z, Hedayati M. The effect of a selected stationary training course on plasma myeloperoxidase in women. Journal of Exercise Physiology and Physical Activity.2011; 8: 647-52.
  21. Ojaghi A, Ghazalian F, Vahdatpour T, Vahedi P,Abednatanzi H, Badalzadeh R. The effect of progressive endurance training on heart resistance induced by infusion ischemia in healthy male rats. Daneshvar Medicine 2021; 29(2):67-77.
  22. Naseri Rad R, Eizadi M. Regular Exercise Training as a Principal Non-Pharmacological Method Affects Serum Leptin and Cardiovascular Risk Factors in Men with Metabolic Syndrome. Arch Med Lab Sci. 2020;6:1-8
  23. Farahati S, Atarzadeh Hosseini S R, Bijeh N, Mahjoob O. The effect of aerobic exercising on plasma nitric oxide level and vessel endothelium function in postmenopausal women. RJMS. 2014; 20 (115):78-88.
  24. Zaros PR, Pires Carla EM, Bacci J, Moraes C, Zanesco A. Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women. BMC Womens Health. 2009; 9:17-25.
  25. Rahimi Moghaddam S R, Elmieh A, Fadaei Chafy M R. The effect of leisure time regular exercise on neutrophil function, myeloperoxidase levels, and antioxidant capacity in middle-aged men. Medical Sciences. 2021; 31(4):413-24.
  26. Morozov VI, Tsyplenkov PV, Golberg ND, Kalinski MI. The effects of high-intensity exercise on skeletal muscle neutrophil myeloperoxidase in untrained and trained rats. European Journal of Applied Physiology. 2006; 97(6):716-22.
  27. Rahimi MR, Naghshini C. The Effect of Caffeine Supplement on Myeloperoxidase and Acetylcholinesterase Activity during Acute Resistance Exercise in Athletes. Journal of Applied Health Studies in Sport Physiolo. 2018, 5(1): 10-17.
  28. Stefanello S, Soares F, Barcelos R. Caffeine supplementation changes inflammatory biomarkers after exercise. J Yoga Phys Ther. 2016; 6(240):2.
  29. Peake J, Wilson G, Hordern M, Suzuki K, Yamaya K, Nosaka K,  et    Changes  in  neutrophil  surface receptor  expression,  degranulation,  and  respiratory burst  activity  after  moderate-and  high-intensity exercise.  Journal of Applied Hysiology. 2004; 97(2):612-8.
  30. Vincent HK,  Bourguignon  CM,  Vincent  KR,  Weltman  AL,  Bryant  M,  Taylor    Antioxidant supplementation lowers exercise-induced oxidative stress in young overweight adults.  Obesity. 2006; 14(12):2224-35.
  31. Hartel C, Strunk T, Bucsky P and Schultz C. Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes. Cytokine. 2004; 27: 101-6.
  32. Kimmons JE, Blanck HM, Tohill BC, Zhang J, Khan LK. Associations between body mass index and the prevalence of low micronutrient levels among us adults. Med Gen Med. 2006; 8(4):59.
  33. Di Giulio RT., Meyer JN. Reactive oxygen species and oxidative stress. In: Di Giulio, R.T., Hinton, D.E. (Eds.), the Toxicology of Fishes. CRC Press, Boca Raton, FL. 2008: 273–324.
  34. Barros AI, Nunes FM, Gonçalves B, Bennett RN, Silva AP. Effect of cooking on total vitamin C contents and antioxidant activity of sweet chestnuts (Castanea sativa Mill). Food Chem. 2011; 128(1):165-72.
  35. Bell JG, Adron JW, Cowey CB. Effect  of  selenium  deficiency  on hydroperoxide  stimulated  release  of  glutathione  from  isolated  perfused  liver  of rainbow trout (Salmo gairdneri). British Journal of Nutrition. 1986; 5(5):421-8.
  36. Jee JP, Lim SJ, Park JS, Kim CK. Stabilization of all-trans retinol by loading lipophilic antioxidants in solid lipid nanoparticles. Eur J Pharm Biopharm. 2006; 63(2):134-9.
  37. Prasad AS, Bao B, Beck FW, Kucuk O, Sarkar FH. Antioxidant effect of zinc in humans. Free Radical Biol. 2004; 37(8):1182-90.
  38. Oya J, Nakagami T, Naito Y, Endo Y, Uchigata Y. Association of Total and Differential White Blood Cell Counts with Physical Energy Expenditure. J Tokyo Wom Med Univ. 2017; 87: 207-16.
  39. Bartlett DB, Shepherd SO, Wilson OJ, Adlan AM, Wagenmakers AJM, Shaw CS, et al. Neutrophil and Monocyte Bactericidal Responses  to  10  Weeks  of  Low-Volume  High-Intensity  Interval  or  Moderate-Intensity Continuous Training in Sedentary Adults. Oxid Med Cell Longev. 2017; 2017:8148742.
  40. Vlasova II. Peroxidase Activity of Human Hemoproteins: Keeping the Fire under Control. Molecules. 2018; 23:2561.
  41. Vlasova II, Sokolov AV, Kostevich VA, Mikhalchik EV, Vasilyev VB. Myeloperoxidase-Induced Oxidation of Albumin and Ceruloplasmin: Role of Tyrosines. Biochemistry (Mosc). 2019; 84:652-62.
  42. Khan AA, Alsahli MA, Rahmani AH. Myeloperoxidase as an Active Disease Biomarker: Recent Biochemical and Pathological Perspectives. Med Sci (Basel). 2018; 6:33.
  43. Groussard C,  Maillard  F,  Vazeille  E,  Barnich  N,  Sirvent  P,  Otero  YF,  et    Tissue-Specific Oxidative Stress Modulation by Exercise: A Comparison between MICT and HIIT in an Obese Rat Model. Oxid Med Cell Longev 2019; 2019:1965364.
  44. Parhofer KG. Increasing HDL-cholesterol and prevention of atherosclerosis: A critical perspective. Atherosclerosis Supplements. 2015; 18, 109-11.
Journal of Nutrition,Fasting and Health
Volume 11, Issue 2
Spring 2023
Pages 124-133

  • Receive Date 09 April 2023
  • Revise Date 11 June 2023
  • Accept Date 14 June 2023