The Correlation between Serum Selenium Concentration and Clinical Outcomes in Critically Ill Paediatric Patients following Major Gastrointestinal Surgeries: A Cross-sectional Study

Document Type : Research Paper


1 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Student Research Committee, faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

6 Immunology Research Centre, Inflammation and Inflammatory Diseases Division, Faculty Member, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran.

7 Social Determinants of Health Research Center, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.


Introduction: Acute-phase inflammatory and oxidative response following major gastrointestinal surgeries may lead to critical conditions in pediatric patients. Selenium plays a key role in the antioxidant defense system and anti-inflammatory pathways, which are important in the clinical outcomes of patients admitted to the pediatric intensive care unit (PICU). The present study aimed to assess the possible correlations between serum selenium levels and clinical outcomes in PICU patients undergoing major gastrointestinal surgeries.
Methods: This cross-sectional study was conducted on 66 critically ill pediatric patients who were in the postoperative stage of major gastrointestinal surgeries. Serum selenium concentration was assessed using the atomic absorption method, and the clinical outcomes were collected prospectively.
Results: Serum selenium concentration upon PICU admission was 38.9±9.8 ng/ml, and no significant correlation was observed between the serum selenium level and the nutritional status of the patients. Furthermore, no significant associations were denoted between the serum selenium concentration and some clinical outcomes, such as the duration of ventilator dependency, PICU length of stay, and PICU/28-day mortality. However, the statistical analysis of the obtained data showed negative, significant associations between the serum selenium concentration, infection rate, and length of hospital stay (P= 0.01 and P=0.04, respectively).
Conclusion: According to the results, serum selenium concentration decreased in the post-gastrointestinal-surgery patients admitted to the PICU upon PICU admission, and the reduction was associated with prolonged hospitalization and a higher infection rate.


Main Subjects

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Volume 12, Issue 2
June 2024
Pages 68-74
  • Receive Date: 08 July 2023
  • Revise Date: 12 September 2023
  • Accept Date: 17 September 2023