A Comparison of the Effects Continuous and Interval Exercises on Fibrillin-1 and Asprosin in Obese Male Rats

Document Type : Research Paper

Authors

1 Department of Basic Sciences, Chabahar Maritime University, Chabahar, Iran.

2 Department of Biochemistry for Sport and Exercise Metabolism, University of Tehran, Tehran, Iran

3 Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.

4 Department of Sport Physiology, Faculty of Physical Education and Sport Science, Ferdowsi University of Mashhad, Mashhad, Iran.

5 Department of Physical Education and Sport Sciences, University of Kurdistan, Sanandaj, Iran

Abstract

Introduction: Obesity is still a health problem for humanity. Although the favorable role of exercise on weight loss has been reported. But the effect of the type of exercise is still unclear. The present study compared the effects of continuous exercise (CE) and interval exercise (IE) on fibrillin-1 and asprosin in obese male rats. Methods: Forty- eight male rats were divided into six groups including 1) obese IE, 2) obese CE, 3) healthy IE, 4) healthy CE, 5) obese control and 6) healthy control. Groups 1- 4 performed exercises for 8 weeks and 72 hours. Insulin resistance index, fasting glucose, insulin, fibrillin-1 and asprosin were measured after the last training session. Data analysis was performed by Two-way analysis of variance and Kruskal-Wallis tests with SPSS software (P≤0.05). Results: There were significant differences in insulin resistance (P=0.001), fibrillin-1 gene expression (P=0.001), fasting glucose (P=0.001), asprosin serum levels (P=0.001), and insulin (P=0.002) levels between obese IE, obese CE, healthy IE, healthy CE, obese control and healthy control groups. Conclusions: Although obesity increased fibrillin-1 and asprosin, but IE and CE decreased fibrillin-1 and asprosin. Thus, IE and CE can be used for controlling fibrillin-1 and asprosin levels. IE and CE can be considered as effective methods to reduce weight in obesity. 

Keywords

Main Subjects

References

  1. Lönn A, Kallings L V, Andersson G, Paulsson S, Wallin P, Eriksson JS, et al. Lifestyle-related habits and factors before and after cardiovascular diagnosis: a case control study among 2,548 Swedish individuals. Int J Behav Nutr Phys Act. 2023;20(1):1–12.
  2. Davari F, Alimanesh Z, Alimanesh Z, Salehi O, Hosseini SA. Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats. Arch Physiol Biochem. 2022;128(5):1215–20.
  3. Chakraborti CK. Role of adiponectin and some other factors linking type 2 diabetes mellitus and obesity. World J Diabetes. 2015;6(15):1296.
  4. Roy PK, Islam J, Lalhlenmawia H. Prospects of potential adipokines as therapeutic agents in obesity-linked atherogenic dyslipidemia and insulin resistance. Egypt Hear J. 2023;75(1):1–28.
  5. Gokee-LaRose J, Gorin AA, Raynor HA, Laska MN, Jeffery RW, Levy RL, et al. Are standard behavioral weight loss programs effective for young adults? Int J Obes. 2009;33(12):1374–80.
  6. Meex RCR, Schrauwen-Hinderling VB, Moonen-Kornips E, Schaart G, Mensink M, Phielix E, et al. Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity. Diabetes. 2010;59(3):572–9.
  7. Tatoń J, Czech A, Piątkiewicz P. Insulin as the main regulator of cellular glucose utilization-aetiological aspects of insulin resistance. Endokrynol Pol. 2010;61(4):388–94.
  8. Hosseini SA, Hamzavi K, Safarzadeh H, Salehi O. Interactive effect of swimming training and fenugreek (Trigonella foenum graecum L.) extract on glycemic indices and lipid profile in diabetic rats. Arch Physiol Biochem. 2023; 129(2):349-53
  9. Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, et al. Asprosin, a fasting-induced glucogenic protein hormone. Cell. 2016;165(3):566–79.
  10. Yuan M, Li W, Zhu Y, Yu B, Wu J. Asprosin: a novel player in metabolic diseases. Front Endocrinol (Lausanne). 2020;11:64.
  11. Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care. 2010;33(12):e147–67.
  12. Asano RY, Sales MM, Browne RAV, Moraes JFVN, Júnior HJC, Moraes MR, et al. Acute effects of physical exercise in type 2 diabetes: a review. World J Diabetes. 2014;5(5):659.
  13. Pirani H, Bakhtiari A, Amiri B, Salehi OR. Beneficial Mitochondrial Biogenesis in Gastrocnemius Muscle Promoted by High-Intensity Interval Training in Elderly Female Rats. Cell J. 2023;25(1):11.
  14. Czech MP. Insulin action and resistance in obesity and type 2 diabetes. Nat Med. 2017;23(7):804–14.
  15. Watts K, Jones TW, Davis EA, Green D. Exercise training in obese children and adolescents. Sport Med. 2005;35(5):375–92.
  16. Alizadeh R, Salehi O, Rezaeinezhad N, Hosseini SA. The effect of high intensity interval training with genistein supplementation on mitochondrial function in the heart tissue of elderly rats. Exp Gerontol. 2023;171:112039.
  17. Mazur-Bialy AI. Asprosin—A Fasting-Induced, Glucogenic, and Orexigenic Adipokine as a New Promising Player. Will It Be a New Factor in the Treatment of Obesity, Diabetes, or Infertility? A Review of the Literature. Nutrients. 2021;13(2):620.
  18. Davis MR, Arner E, Duffy CRE, De Sousa PA, Dahlman I, Arner P, et al. Expression of FBN1 during adipogenesis: Relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions. Mol Genet Metab. 2016;119(1–2):174–85.
  19. Triplitt C, DeFronzo RA. Exenatide: first-in-class incretin mimetic for the treatment of type 2 diabetes mellitus. Expert Rev Endocrinol Metab. 2006;1(3):329–41.
  20. Elnagar A, El-Dawy K, El-Belbasi HI, Rehan IF, Embark H, Al-Amgad Z, et al. Ameliorative Effect of Oxytocin on FBN1 and PEPCK Gene Expression, and Behavioral Patterns in Rats’ Obesity-Induced Diabetes. Front Public Heal. 2022;10.
  21. Rose AJ, Frøsig C, Kiens B, Wojtaszewski JFP, Richter EA. Effect of endurance exercise training on Ca2+–calmodulin‐dependent protein kinase II expression and signalling in skeletal muscle of humans. J Physiol. 2007;583(2):785–95.
  22. O’neill HM. AMPK and exercise: glucose uptake and insulin sensitivity. Diabetes Metab J. 2013;37(1):1–21.
Journal of Nutrition,Fasting and Health
Volume 12, Issue 1
March 2024
Pages 7-13

Files

History

  • Receive Date: 18 April 2023
  • Revise Date: 03 September 2023
  • Accept Date: 07 October 2023

Share

How to cite

Statistics