Journal of Nutrition,Fasting and Health

Journal of Nutrition,Fasting and Health

Simultaneous Effect of Atorvastatin and Combined Training on lipid and hepatic enzymes in Rats induced Non-Alcoholic Fatty Liver Disease

Document Type : Research Paper

Authors
Seyed Ali Mirghani 1
Mania Roozbayani 2
Saleh Rahmati 3
Lida Moradi 4
1 Department of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University Tehran, Iran.
2 Department of Exercise Physiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran.
3 Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.
4 Department of Physical Education and Sports Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
10.22038/jnfh.2023.75312.1466
Abstract
Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, the prevalence of which is increasing. This study aimed to evaluate the effect of atorvastatin and combined training in NAFLD-induced rats. Methods: This study was conducted on 21 male Wistar rats, divided into two groups: 1) HFFD + combined training + atorvastatin and 2) HFFD + atorvastatin. The groups received HFFD for 15 weeks to induce NAFLD. Atorvastatin was administrated at the dose of 2mg/kg/day. The interventions (atorvastatin and combined training) were performed for eight weeks. Results: Alanine transaminase (ALT) was significantly reduced, and high-density lipoprotein (HDL) was increased in the HFFD + atorvastatin group. Low-density lipoprotein (LDL) decreased significantly in the HFFD + combined training + atorvastatin. There was no significant difference in the aspartate transaminase (AST), triglyceride (TG), alkaline phosphatase (ALP), and weight between the groups. Conclusion: Based on the findings, Atorvastatin, along with combined training, improved NAFLD. Therefore, they can be used to reduce the complications of NAFLD. However, more studies are needed to confirm the results.
Keywords
Atorvastatin
High-fat-fructose diet
Non-alcoholic fatty liver disease
Combined training
Subjects
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Journal of Nutrition,Fasting and Health
Volume 11, Issue 3
Summer 2023
Pages 246-252

  • Receive Date 02 October 2023
  • Revise Date 04 November 2023
  • Accept Date 05 November 2023