The Effect of Royal Jelly and Endurance Exercise on Cognitive Function and Pathological Changes of Hippocampus Tissue in Rats with Experimental Autoimmune Encephalomyelitis

Document Type : Research Paper


Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.


Introduction: Although the positive effects of physical trainings as well as nutrition on cognitive function are reported. But there is limited information regarding their combined effect. Present study aimed to review the effect of royal jelly (RJ) and endurance exercise (EE) on cognitive function and pathological changes of hippocampus tissue in rats with experimental autoimmune encephalomyelitis (EAE). Methods: Forty- nine Sprague- Dawley female EAE rats selected as sample and assigned in 1) EE+RJ100, 2) EE+RJ50, 3) EE, 4) RJ100, 5) RJ50, 6) Sham (Sh), and 7) EAE groups also 7 healthy rats assigned in healthy control group (HC). Rats in EE groups trained 4 sessions per week (30 minutes with speed of 11-15 m/min) for five weeks and RJ was injected intra- peritoneal. One-way ANOVA along with Tukey's post hoc was used for data analysis (P≤0.05). Results: The percentage of healthy cells in the C1 region (PHC), avoidance (AM) and spatial memory (SM) levels in the EE group were more favorable than the EAE group (P≤0.05). Also, the PHC in the C3 and C1 regions, the AM and SM values in the RJ50 and RJ100 groups were higher than the EAE group (P≤0.05). As well as the PHC in C1 and C3 regions, AM and SM levels in the EE+RJ50 and EE+RJ100 groups were significantly more favorable than the EAE group (P≤0.05). The effects of EE+RJ50 and EE+RJ100 on improving SM and some subsections of AM were more favorable than the effects of RJ100 (P≤0.05). Conclusion: Although EE and RJ (50 and 100mg/kg) alone and their interactive effects have favorable effects on improving memory and neurogenesis.


Main Subjects

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