Synergistic Effect of High Intensity Interval Training and Atorvastatin in Treatment of NAFLD in Rats Fed High Fat/Fructose Diet

Document Type : Research Paper


1 Department of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University Tehran, Iran

2 Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.

3 Department of Physical Education and Sports Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran


Introduction: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease that ranges from steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and liver carcinoma. With the increasing prevalence of NAFLD, there is a growing need for effective prevention and treatment strategies. Stable pharmaceutical compositions containing atorvastatin have been developed to treat hypercholesterolemia and related conditions. In addition, high-intensity interval training (HIIT) can have positive effects on NAFLD. Methods: Twenty-one male Wistar rats were divided into 2 groups: 1) high fat-fructose diet (HFFD) + HIIT, 2) HFFD + HIIT + atorvastatin. The groups received HFFD for 15 weeks to induce NAFLD. Atorvastatin was administrated at the dose of 2 mg/kg/day. The interventions (atorvastatin and HIIT) were done for 8 weeks. Results: Triglyceride (TG), Alanine transaminase (ALT), and aspartate transaminase (AST) were significantly reduced in the HFFD + HIIT + atorvastatin. The groups had no significant difference in weight, low-density lipoprotein (LDL), alkaline phosphatase (ALP), and HDL/LDL ratio.


Main Subjects

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Articles in Press, Accepted Manuscript
Available Online from 06 January 2024
  • Receive Date: 02 October 2023
  • Revise Date: 05 January 2024
  • Accept Date: 06 January 2024