The Effect of an Aerobic Exercise Session in Fasting Versus Satiety on Fat and Carbohydrate Oxidation in Hypoxia and Normoxia in Overweight Men

Articles in Press

Document Type : Research Paper

Authors

Faculty of Physical Education and Sports Sciences, Razi University, kermanshah, Iran.

Abstract

Introduction: This study aimed to the effect of an aerobic exercice session in fasting versus satiety on fat and carbohydrate oxidation in hypoxia and normoxia in overweight men.Methods: Sixteen overweight men, with a body mass index (BMI) ranging between 25-29.9, a mean age of 30.75 ± 6.79 years, and maximum oxygen consumption of 24.67 ± 4.61 liters per minute, voluntarily participated in the study. Each participant underwent four conditions, including fasting hypoxia, normal hypoxia, fasting normoxia, and normal normoxia. during the study, the participants completed a 30-minute aerobic test on a CUCLUS2 bike with a heart rate (bp/m) of 60-70% in a hypoxia tent at an altitude of 3000 meters and 14.5% oxygen, or in normoxia condition in the laboratory facilities of Razi University of Kermanshah Sports Sciences Faculty. In the satiated state, the participants were provided with two pieces of toast, one tablespoon of peanut butter, and one glass of milk. The breathing gases were collected for 30 minutes to evaluate fat and carbohydrate oxidation. Results: The results of the study showed that fat oxidation was significantly higher in the fasted group than in the satiety group (p<0.05) in both hypoxia and normoxia conditions. Moreover, fat oxidation in normoxia was significantly higher than in hypoxia (p<0.05). In contrast, carbohydrate oxidation and respiratory exchange ratio were significantly lower in the fasted group than in the satiety group (p<0.05).Conclusion: Based on the findings of the study, it can be concluded that training in a hypoxia state, whether fasting or full, is a suitable non-invasive method to tackle obesity and overweight.

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References

  1. Khani E, Hovanlu F, Ahmadizad S. The Effect of Interval Exercise at Different Hypoxia Intensities on Responses of Acylated Ghrelin and Appetite in Overweight Subject. Iranian Journal of Endocrinology and Metabolism. 2018;20(1):31-7.
  2. Kazemi Nasab Fatemeh AS, Shujaei Muhaddeh. Comparison of the effect of high-intensity interval training and moderate-intensity continuous training on cardiometabolic factors in overweight and obese children and adolescents: a systematic review and meta-analysis. Faiz [Internet]. 1402;27(3):326-339. Available from: https://sid.ir/paper/1083079/fa.
  3. Hariharan R, Odjidja EN, Scott D, Shivappa N, Hébert JR, Hodge A, et al. The dietary inflammatory index, obesity, type 2 diabetes, and cardiovascular risk factors and diseases. Obesity Reviews. 2022;23(1):e13349.
  4. forooghi nasab f, Hovanloo F, Ahmadizad S. The Effect of Interval Exercise in Hypoxia on Responses of PYY3-36 and Appetitein Overweight Individuals. Iranian Journal of Endocrinology and Metabolism. 2016;18(2):105-11.
  5. Fenkci S, Sarsan A, Rota S, Ardic F. Effects of resistance or aerobic exercises on metabolic parameters in obese women who are not on a diet. Advances in therapy. 2006;23:404-13.
  6. Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, et al. Aerobic or resistance exercise, or both, in dieting obese older adults. New England Journal of Medicine. 2017;376(20):1943-55.
  7. Said MA, Abdelmoneem M, Almaqhawi A, Kotob AAH, Alibrahim MC, Bougmiza I. Multidisciplinary approach to obesity: Aerobic or resistance physical exercise? Journal of Exercise Science & Fitness. 2018;16(3):118-23.
  8. Lundsgaard A-M, Fritzen AM, Kiens B. Molecular regulation of fatty acid oxidation in skeletal muscle during aerobic exercise. Trends in Endocrinology & Metabolism. 2018;29(1):18-30.
  9. Jiang Y, Tan S, Wang Z, Guo Z, Li Q, Wang J. Aerobic exercise training at maximal fat oxidation intensity improves body composition, glycemic control, and physical capacity in older people with type 2 diabetes. Journal of exercise science & fitness. 2020;18(1):7-13.
  10. Zaghian N, Darvishi L, Askari G, Ghiasvand R. Impact of fat adaptation on metabolism and sport performance:A review of the current evidence. Iranian Journal of Nutrition Sciences and Food Technology. 2013;8(3):113-22.
  11. Melzer K. Carbohydrate and fat utilization during rest and physical activity. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism. 2011;6(2):e45-e52.
  12. Brinkworth GD, Noakes M, Clifton PM, Buckley JD. Effects of a low carbohydrate weight loss diet on exercise capacity and tolerance in obese subjects. Obesity. 2009;17(10):1916-23.
  13. Spriet LL, Watt MJ. Regulatory mechanisms in the interaction between carbohydrate and lipid oxidation during exercise. Acta Physiologica Scandinavica. 2003;178(4):443-52.
  14. Vieira AF, Costa RR, Macedo RCO, Coconcelli L, Kruel LFM. Effects of aerobic exercise performed in fasted v. fed state on fat and carbohydrate metabolism in adults: a systematic review and meta-analysis. British Journal of Nutrition. 2016;116(7):1153-64.
  15. Kim TW, Lee SH, Choi KH, Kim DH, Han TK. Comparison of the effects of acute exercise after overnight fasting and breakfast on energy substrate and hormone levels in obese men. Journal of physical therapy science. 2015;27(6):1929-32.
  16. Iwayama K, Kawabuchi R, Nabekura Y, Kurihara R, Park I, Kobayashi M, et al. Exercise before breakfast increases 24-h fat oxidation in female subjects. PLoS One. 2017;12(7):e0180472.
  17. Hall KD, Bemis T, Brychta R, Chen KY, Courville A, Crayner EJ, et al. Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity. Cell metabolism. 2015;22(3):427-36.
  18. Horowitz JF, Mora-Rodriguez R, Byerley LO, Coyle EF. Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise. American Journal of Physiology-Endocrinology and Metabolism. 1997.
  19. Griffiths A, Deighton K, Shannon OM, Boos C, Rowe J, Matu J, et al. Appetite and energy intake responses to breakfast consumption and carbohydrate supplementation in hypoxia. Appetite. 2020;147:104564.
  20. Czuba M, Zając A, Maszczyk A, Roczniok R, Poprzęcki S, Garbaciak W, et al. The effects of high intensity interval training in normobaric hypoxia on aerobic capacity in basketball players. Journal of human kinetics. 2013;39:103.
  21. Azizi M, Mohammadi P, Tahmasebi W . The effect of 8 weeks of exercise training in hypoxia and normoxia on irisin levels and insulin resistance index in overweight men. Journal of Sport and Exercise Physiology. 2021;13(2):87-95.
  22. Park H-Y, Kim J, Park M-Y, Chung N, Hwang H, Nam S-S, et al. Exposure and exercise training in hypoxic conditions as a new obesity therapeutic modality: a mini review. Journal of Obesity & Metabolic Syndrome. 2018;27(2):93.
  23. Mohammadzadeh M, Soori R, Choobineh S. The Effect of Training in Normoxia and Hypoxia Conditions on Erythropoietin Levels and Physical Performance in Elite Endurance Runners. Sport Physiology &Management Investigations. 2020;11(4):23-35.
  24. Ghanbarzadeh F, Mohiti Ardekani J, zavarreza J. Effect of Curcumin on Phosphorylation of AMPK and ACC in C2C12 Skeletal Muscle Cells. The Journal of Shahid Sadoughi University of Medical Sciences. 2013;21(4):482-92.
  25. Iwayama K, Kawabuchi R, Park I, Kurihara R, Kobayashi M, Hibi M, et al. Transient energy deficit induced by exercise increases 24-h fat oxidation in young trained men. Journal of Applied Physiology. 2015.
  26. Slater T, Mode WJ, Pinkney MG, Hough J, James RM, Sale C, et al. Fasting before evening exercise reduces net energy intake and increases fat oxidation, but impairs performance in healthy males and females. International journal of sport nutrition and exercise metabolism. 2022;33(1):11-22.
  27. Azizi M, Mohebi, Hamid. Comparison of the effect of sports activity with different intensities in the morning and evening on maximum fat oxidation in obese and normal weight men. Journal of Applied Sports Physiology, 2013; 10(19): 28-39. doi: 10.22080/jaep.2014.815.
  28. Bassami M, Ahmadizad S, Tahmasebi W, Khedmatgozar E, Rokhsati S. Effects of Ramadan Fasting and Regular Exercise Training on Fat and CHO Metabolism. Iranian Journal of Endocrinology and Metabolism. 2013;15(4):360-9.
  29. Kelly LP, Basset FA. Acute normobaric hypoxia increases post-exercise lipid oxidation in healthy males. Frontiers in Physiology. 2017;8:293.
  30. Lundby Ce, Van Hall G. Substrate utilization in sea level residents during exercise in acute hypoxia and after 4 weeks of acclimatization to 4100 m. Acta physiologica scandinavica. 2002;176(3):195-201.
  31. Sumi D, Hayashi N, Yatsutani H, Goto K. Exogenous glucose oxidation during endurance exercise in hypoxia. Physiological Reports. 2020;8(13):e14457.
  32. Goodman MN. Influence of aerobic exercise on fuel utilization by skeletal muscle. ACS Publications; 1986.
  33. Stannard SR, Thompson MW, Fairbairn K, Huard B, Sachinwalla T, Thompson CH. Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men. American Journal of Physiology-Endocrinology and Metabolism. 2002;283(6):E1185-E91.
  34. Holloszy JO, Booth FW. Biochemical adaptations to endurance exercise in muscle. Annual review of physiology. 1976;38(1):273-91.
  35. Haghdoost A, Poorranjbar M. The interaction between physical activity and fasting on the serum lipid profile during Ramadan. Singapore Med J. 2009;50(9):897-901.
  36. Kaabi S, Moradi, Lida, Alizadeh, Rostam. The effect of 6 weeks of aerobic training in hypoxic conditions on the resting levels of nesfatin-1 and insulin resistance in overweight women. Sports Biology Journal, 2018; 11(4): 463-475. doi: 10.22059/jsb.2019.253800.1253.
  37. Ofner M, Wonisch M, Frei M, Tschakert G, Domej W, Kröpfl JM, et al. Influence of acute normobaric hypoxia on physiological variables and lactate turn point determination in trained men. Journal of sports science & medicine. 2014;13(4):774.
  38. Hozouri T, Fashi, Mohammad, Hasanlui, Hamida... The effect of four weeks of polarized training on aerobic fitness and performance of professional rowers. Sports Physiology and Physical Activity Journal, 1401; 15(4): 31-41. doi: 10.52547/joeppa.15.4.31.
  39. Hamlin M, Marshall H, Hellemans J, Ainslie P, Anglem N. Effect of intermittent hypoxic training on 20 km time trial and 30 s anaerobic performance. Scandinavian journal of medicine & science in sports. 2010;20(4):651-61.
  40. Rosmond R, Dallman MF, Björntorp P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. The Journal of Clinical Endocrinology & Metabolism. 1998;83(6):1853-9.
  41. Westerbacka J, Yki-Järvinen H, Vehkavaara S, Häkkinen A-M, Andrew R, Wake DJ, et al. Body fat distribution and cortisol metabolism in healthy men: enhanced 5β-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. The Journal of Clinical Endocrinology & Metabolism. 2003;88(10):4924-31.
  42. Rowell LB, Johnson DG, Chase PB, Comess KA, Seals DR. Hypoxemia raises muscle sympathetic activity but not norepinephrine in resting humans. Journal of Applied Physiology. 1989;66(4):1736-43.
Journal of Nutrition,Fasting and Health

Articles in Press, Accepted Manuscript
Available Online from 24 June 2024

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  • Receive Date: 07 February 2024
  • Revise Date: 20 June 2024
  • Accept Date: 24 June 2024

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