The Effect of Detraining Followed by Endurance Training and Salvia Officinalis supplementation on Psychological Indicators and Physiological Performance in Rats

Articles in Press

Document Type : Research Paper

Authors

Departmen of Sport Physiology, Marv.C., Islamic Azad Univercity, Marvdasht, Iran.

Abstract

Introduction: This study examined the effects of two and four weeks of detraining, followed by four weeks of endurance training (ET) and Salvia officinalis (S) supplementation, on anxiety-like behaviors, aerobic capacity (AC), depression, and pain threshold (PT) in rats. Methods: In this experimental study, 40 adult female rats were randomly assigned to five groups: (1) Control, (2) Sham, (3) S, (4) ET, and (5) ETS. Rats in groups 4 and 5 underwent treadmill training for four weeks (five sessions per week, 60 minutes per session). Groups 3 and 5 received Salvia officinalis extract at 100 mg/kg/day. Data were analyzed using analysis of covariance (ANCOVA) and one-way analysis of variance (ANOVA) with repeated measures. Results: The percentage of time spent in the open arms (OA) of the elevated plus maze in the S, ET, and ETS groups was significantly higher than in the control group during both two and four weeks of detraining. However, after four weeks of detraining, this percentage was significantly lower compared to two weeks of detraining (P ≤ 0.05). No significant differences were observed in AC, depression levels, or PT between the two- and four-week detraining periods following four weeks of ET+S (P ≤ 0.05). Conclusion: The findings suggest that four weeks of Salvia officinalis supplementation and endurance training can reduce anxiety-like behaviors. However, two and four weeks of detraining may lead to an increase in anxiety-like behaviors.

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References

  1. Yao CA, Rhodes RE. Parental correlates in child and adolescent physical activity: a meta-analysis. Int J Behav Nutr Phys Act. 2015;12:1–38.
  2. Hosseini SA, Norouzi S, Rafiee N, Farzanegi P, Salehi O, Farkhaie F. Interactive Effects of Endurance Training and Crocin on Aerobic Capacity, Dietary Intake and Weight of High-Fat Diet-Induced Type 2 Diabetic Rats. J Nutr Sci Diet. 2018;4(3).
  3. Ahmadi DK. The Comparison efficiency of two kind of morning exercise training on Lipid Profile of Teenagers in 2012. 2013; 18-24.
  4. Williams CL, Hayman LL, Daniels SR, Robinson TN, Steinberger J, Paridon S, et al. Cardiovascular health in childhood: a statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 2002;106(1):143–60.
  5. Hosseini SA, Salehi O, Keikhosravi F, Hassanpour G, Ardakani HD, Farkhaie F, et al. Mental health benefits of exercise and genistein in elderly rats. Exp Aging Res. 2022;48(1):42–57.
  6. Hosseini SA, Hamzavi K, Safarzadeh H, Salehi O. Interactive effect of swimming training and fenugreek (Trigonella foenum graecum L.) extract on glycemic indices and lipid profile in diabetic rats. Arch Physiol Biochem. 2023;129(2):349–53.
  7. Ghanbari P, Khajehzadeh S, Sayyed A, Raeisi D, Salehi O. The effect of high intensity interval training with beetroot (Beta vulgaris) juice supplementation on serotonin and dopamine receptors expression, anxiety and depression in middle-aged diabetic rats. Avicenna J Phytomedicine. 2022; 12(6):627-37.
  8. Hosseini SA, Salehi OR, Farzanegi P, Farkhaie F, Darvishpour AR, Roozegar S. Interactive Effects of Endurance Training and Royal Jelly Consumption on Motor Balance and Pain Threshold in Animal Model of the Alzheimer Disease. Arch Neurosci. 7(2):e91857.
  9. Arammi S, Sahragard M, Seyed A, Salehi O, Hosseini SA, Mosallanezhad Z. The effects of swimming training at different temperatures along with cinnamon supplementation on liver enzymes and thyroid hormones in diabetic rats. Avicenna J Phytomedicine. 2024; 14(1):126-37.
  10. Salehi O, Sheikholeslami-Vatani D, Negarandeh Z, Yarahmadi J. The effect of swimming training at different temperatures with cinnamon consumption on avoidance memory, spatial memory and aerobic power in streptozotocin-induced diabetic rats. 2020; 1(1).
  11. Schuch FB, Vancampfort D. Physical activity, exercise, and mental disorders: it is time to move on. Trends psychiatry Psychother. 2021;43(3):177–84.
  12. Dabidi roshan, V., Gaeeni, A. A., Ravasi, A. A. The Effect of 4 Weeks of Detraining after 12 Weeks of Continuous and Intermittent Aerobic Training on High Sensitive C-Reactive Protein in Rats. 2007; 1-14.
  13. Coyle EF, Martin WH, Holloszy JO. Cardiovascular and metabolic rates of detraining. Med Sci Sport Exerc. 1983;15(2):158.
  14. Costill DL, Gollnick PD, Jansson ED, Saltin B, Stein EM. Glycogen depletion pattern in human muscle fibres during distance running. Acta Physiol Scand. 1973;89(3):374–83.
  15. Costill DL, Fink WJ, Hargreaves M, King DS, Thomas R, Fielding R. Metabolic characteristics of skeletal muscle during detraining from competitive swimming. Med Sci Sports Exerc. 1985;17(3):339–43.
  16. Hosseinzadeh H, Ziaei T. Effects of Crocus sativus stigma extract and its constituents, crocin and safranal, on intact memory and scopolamine-induced learning deficits in rats performing the Morris water maze task. J Med Plants. 2006;5(19):40–50.
  17. Alijanpour B, Sheidai M. Numerical taxonomy study of Salvia L.(Lamiacae) species in southern slope of Central Alborz, Iran. Nov Biol Reper. 2017;4(2):107–15.
  18. Salehi OR, Hosseini SA, Farkhaie F, Farzanegi P, Zar A. The Effect of Moderate Intensity Endurance Training with Genistein on Brain-Derived Neurotrophic Factor and Tumor Necrosis Factor-αin Diabetic Rats. J Nutr Fasting Heal. 2019;7(1):44–51.
  19. Shahinfar J, Zeraati H, Nasimi F, Shojaei S. Effect of medicinal plants on anxiety, a review article. 2017.
  20. Hosseini MA, Shirzad F, Ahmadzad-Asl M, Hadi F. Depression, Anxiety, Stress, and Resiliency in Iranian Families with Autistic Children. J Adv Med Biomed Res. 2022;30(139):123–8.
  21. Bakhtiari-Dovvombaygi H, Askari M, Rahimkhani M, Abdollahi M, Baladastian M, Alipour A, et al. Prevalence of death anxiety and its related factors in the population of eastern Iran: a cross-sectional study in the era of COVID-19. Front Public Heal. 2024;12:1427995.
  22. Jangi Jahantigh L, Latifi Z, Soltanizadeh M. Effect of self-healing training on death anxiety and sleep quality of older women living in nursing homes. Iran J Ageing. 2022;17(3):380–97.
  23. Li L, Wang C, Wang D, Li H, Zhang S, He Y, et al. Optimal exercise dose and type for improving sleep quality: a systematic review and network meta-analysis of RCTs. Front Psychol. 2024;15:1466277.
  24. Patel A, Cheung J. The Effect of Exercise on Daytime Sleepiness in Healthy Individuals. Sleep Med. 2024.
  25. Motaghi S, Teimouri M. Investigation of anxiolytic and hypnotic effects of aqueous and hydroalcoholic extracts of salvia officinalis in adult mice. Iran J Physiol Pharmacol [Internet]. 2018;2(3). Available from: http://ijpp.phypha.ir/article-1-303-en.html
  26. Hanrahan JR, Chebib M, Johnston GAR. Interactions of flavonoids with ionotropic GABA receptors. Adv Pharmacol. 2015;72:189–200.
  27. Johnston GAR. Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA. Neurochem Int. 2015;89:120–5.
  28. Sadeghi A H, Bakhshi M, Behboodi Z, Goodarzi S, Haghani H. Effect of sage extract on hot flashes in postmenopausal women. Complement Med J. 2013;2(4):324–35.
  29. Viola H, Wasowski C, Marder M, Wolfman C, Paladini AC, Medina JH. Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle, Cirsiliol. Phytomedicine. 1997;4(1):47–52.
  30. Kavvadias D, Monschein V, Sand P, Riederer P, Schreier P. Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med. 2003;69(02):113–7.
  31. Karami M, Hossini E, Shahbi Majd N, Ebrahimzadeh MA, Alemy S. Salvia limbata: Botanical, Chemical, Pharmacological and Therapeutic Effecte. Clin Excell [Internet]. 2015;3(2).

 

 

Journal of Nutrition,Fasting and Health

Articles in Press, Accepted Manuscript
Available Online from 04 February 2025

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History

  • Receive Date: 30 July 2024
  • Revise Date: 04 January 2025
  • Accept Date: 04 February 2025

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