Metabolic Effects of Cryolipolysis in Overweight Individuals on a Low-Calorie Diet: Protocol for a Randomized Controlled Trial

Articles in Press

Document Type : Protocol Study

Authors

1 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran

2 Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of radiology, Mashhad Branch, Islamic Azad University, Mashhad, Iran

4 Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

5 Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK

6 Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction: Obesity, with its associated health risks, remains a major global concern. While traditional methods of weight management have their limitations, new non-invasive options, such as Cryolipolysis, have been gaining attention. Cryolipolysis is a non-invasive procedure that selectively targets and eliminates fat cells by freezing them. This study aims to investigate the metabolic effects of cryolipolysis in combination with a low-calorie diet. Methods: This randomized controlled clinical trial aims to investigate the effects of Cryolipolysis in combination with a standardized low-calorie diet in 50 overweight women aged 18-65 years. Participants will be randomly assigned to one of three groups: combination of cryolipolysis and low-calorie diet, or a low-calorie diet only. Metabolic parameters such as body composition, fat layer thickness, and various biochemical parameters, including fasting blood glucose levels, lipid profile, and renal and liver function tests profile will be measured at baseline and at the end of the study. Discussion: This study will provide valuable insights into the metabolic effects of combining cryolipolysis with a low-calorie diet. Understanding how these interventions interact at a metabolic level can inform the development of more effective weight loss strategies.

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References

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Journal of Nutrition,Fasting and Health

Articles in Press, Accepted Manuscript
Available Online from 09 July 2025

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History

  • Receive Date: 16 March 2025
  • Revise Date: 01 July 2025
  • Accept Date: 09 July 2025

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