Journal of Nutrition,Fasting and Health

Journal of Nutrition,Fasting and Health

The Positive Role of Probiotics in Controlling and Treating Gestational Diabetes in Pregnancy

Document Type : Review Article

Authors
Nazanin Zeinab Hajmollarezaei 1
Nargess Sadat Yaghoubi All 1
Ezat Hajmollarezaei 2
1 Assistant Professor, Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Obestetrics & Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
10.22038/jnfh.2025.88337.1585
Abstract
Introduction: Diabetes, including gestational diabetes mellitus (GDM), has a high global prevalence and remains a significant public health concern. The pathophysiology of GDM involves carbohydrate intolerance and can have substantial effects on pregnancy outcomes. Probiotics—naturally occurring microorganisms in the human gut—have been suggested to confer health benefits. Inflammatory processes play a central role in the development of GDM, and probiotics may influence immune system function and modulation. This study aims to explore the potential role of probiotics as a therapeutic intervention for GDM through a comprehensive review of the literature published between 2010 and 2024. Key search terms included: "probiotics," "symbiosis," "Bifidobacterium," "Lactobacillus," "gestational diabetes," "infantile consequences," and "metabolic profile." Only studies involving human subjects were included in this review. Methods: A comprehensive review of literature from 2010 to 2024 was conducted to clarify the role of probiotics as a treatment for GDM. Key search terms included "probiotics," "symbiosis," "bifidobacterium," "Lactobacillus," "Gestational diabetes," "Infantile consequences," and "Metabolic profile." This research includes human articles. Results: Although the evidence is limited, probiotics have a positive effect on blood glucose levels and reduce insulin resistance, making them potentially effective in treating GDM. Conducting more studies on different types of probiotics and in larger patient populations can provide further insights into this issue.
Keywords
Gestational diabetes
Probiotics
Insulin resistance
Subjects
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Journal of Nutrition,Fasting and Health
Volume 14, Issue 2
Spring 2026
Pages 85-93

  • Receive Date 19 May 2025
  • Revise Date 13 July 2025
  • Accept Date 15 July 2025