The Effect of 12 Weeks Combined Training with Nettle Supplement on IL-18 and IL-10 in Women with Type 2 Diabetes

Articles in Press

Document Type : Research Paper

Author

Assistant Professor of Exercise Physiology, Faculty of Sport Sciences, Maragheh University, Maragheh, Iran.

Abstract

Introduction: Inflammatory factors are known to be one of the most important causes in the development of cardiovascular diseases and type 2 diabetes; while regular exercise with anti-inflammatory effects can suppress mild systemic inflammation in type 2 diabetes. Thus, the purpuse of this research was to examine the impact of combined exercise with nettle supplementation on IL-18 and IL-10 levels, glucose, and insulin resistance in diabetic women. Methods: Sixty women with type 2 diabetes voluntarily participated in the study and were divided into four groups: 1: combined training (Com), 2: Nettle supplement (NS), 3: combined training + Nettle (Com+NS) 4: Control group. The subjects in the training group practiced resistance training (40-70% 1RM) and aerobic interval training (60-75% MHR) for 12 weeks with three sessions every week. Serum levels of fasting blood glucose, insulin, HbA1C, IL-18, IL-10 and insulin resistance index were measured. Data were analyzed using analysis of variance. Results: There was a significant reduce in insulin, blood glucose and insulin resistance, and IL-18 levels in the Com, NS, and Com + NS groups compared to the control group (p <0.05). Also, IL-10 levels in the Com, NS, and Com + NS groups were significantly increased compared to the control group (p <0.05). Conclusion: It suggests that both combined training intervention methods and nettle supplement are effective methods in blood glucose control and reducing inflammation and the combination of these two methods is more effective in glycemic control in diabetic patients.

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References

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Journal of Nutrition,Fasting and Health

Articles in Press, Accepted Manuscript
Available Online from 18 August 2025

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History

  • Receive Date: 16 February 2025
  • Revise Date: 01 June 2025
  • Accept Date: 03 June 2025

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