Fasting In A 16-year-old Girl At-risk of Autosomal Dominant Polycystic Kidney Disease

Document Type : Case Report


1 Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Medical Genetics, Mashhad University of Medical Sciences, Mashhad, Iran


Autosomal dominant polycystic kidney disease (ADPKD) is the most common form of inherited kidney disease that results in renal failure. PKD currently has no causative therapy. However, some treatment options are available, ranging from symptomatic therapy to delaying the onset of end-stage renal failure. Early diagnosis of adult polycystic kidney disease is vital in order to prevent its complications. Ultrasonongraphy and genetic testing are the two preferred diagnostic techniques with defined limitations, mainly regarding age. Herein, we report a case of an ADPKD family whom visited the genetic counseling clinic for determining the disease risk in their symptom-free girls aged 16 and 22 years, and discussing other related issues such as their concern about fasting in Ramadan.


  1. Grantham JJ. Clinical practice. Autosomal dominant polycystic kidney disease. The New England journal of medicine. 2008;359(14):1477-85.
  2. Pei Y. Practical genetics for autosomal dominant polycystic kidney disease. Nephron Clin Pract. 2011;118(1):c19-30.
  3. Wu G, Somlo S. Molecular genetics and mechanism of autosomal dominant polycystic kidney disease. Molecular genetics and metabolism. 2000;69(1):1-15.
  4. Guay-Woodford LM. Phenotypic variability in PKD1: The family as a starting point. Kidney international. 1999;56(1):344-6.
  5. Harris PC, Torres VE. Polycystic kidney disease, autosomal dominant. 2011.
  6. Chauveau D, Pirson Y, Vereleen-Dumoulin C, Macnicol A, Gonzalo A, Grunfeld J-P. Intracranial aneurysms in autosomal dominant polycystic kidney disease. Kidney international. 1994;45(4):1140-6.
  7. Sahney S, Weiss L, Levin NW, Opitz JM. Genetic counseling in adult polycystic kidney disease. American journal of medical genetics. 1982;11(4):461-8.
  8. Pei Y, Watnick T. Diagnosis and screening of autosomal dominant polycystic kidney disease. Advances in chronic kidney disease. 2010;17(2):140-52.
  9. Bajwa ZH, Gupta S, Warfield CA, Steinman TI. Pain management in polycystic kidney disease. Kidney international. 2001;60(5):1631-44.
  10. Tan Y-C, Blumenfeld J, Rennert H. Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2011;1812(10):1202-
  11. Pei Y. Diagnostic approach in autosomal dominant polycystic kidney disease. Clinical Journal of the American Society of Nephrology. 2006;1(5):1108-14.
  12. Polycystic Kidney Disease, Autosomal Dominant [database on the Internet]. 2011 [cited 4/23/2015]. Available from:
  13. El-Wakil H, Desoky I, Lotfy N, Adam A. Fasting the month of Ramadan by Muslims: could it be injurious to their kidneys? Saudi Journal of Kidney Diseases and Transplantation. 2007;18(3):349.
  14. NasrAllah MM, Osman NA. Fasting during the month of Ramadan among patients with chronic kidney disease: renal and cardiovascular outcomes. Clinical kidney journal. 2014:sfu046.