The Effects of Fasting on Physiological Status and Gene Expression; An Overview

Document Type : Review Article


Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


Calorie restriction through ingesting no or minimal amounts of food and caloric beverages for periods of time is called fasting. Fasting can affect body through changing in physical and metabolic adaptations, as well as mineral and hormonal status. However, psychological effects and sometimes medical complications are likely in case of inappropriate fasting. Fasting is associated with changes in expression of different genes and signaling pathways. In this brief review, physiological effects of fasting, affected pathways during fasting and potential applications of fasting are discussed.


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