Document Type : Review Article
Department of Biology, Faculty of Science, University of Zabol, Zabol, Islamic Republic of Iran
Institute of Social Security & Welfare Applied Science Higher Education Tehran Province, University of Applied Science and Technology, Tehran, Iran.
Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Osteoporosis is considered as one of the most common diseases that women face after their menopause and is caused by both genetic and environmental factors. Dipeptidyl peptidase 4 (DPP-4) gene is one of the important genetic factors contributing in osteoporosis which has a direct and very important relationship with fasting. Fasting is one of the alternatives proved to reduce the DPP-4 level and activate the Dipeptidyl peptidase 4 inhibitors and so, prevent osteoporosis. On the other hand, the circadian rhythm has a direct relationship with osteoporosis. This has been found by the biochemical markers, indicating that fasting at certain hours of the day, especially during those hours of the day which are recommended as part of the Muslim tradition, is very effective in reducing the effects of osteoporosis.