The Effect of Vitex Castus Extract and Exercise Training on Psychological and Physical Symptoms of Premenstrual Syndrome in Young Girls

Document Type : Research Paper


1 Master students, Department of Physical Education and Sport Sciences, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran.

2 Department of Physical Education and Sport Sciences, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran.

3 Department of Midwifery, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran.


Introduction: Premenstrual Syndrome (PMS) is a psycho-neuroendocrine disorder in which biological, psychological, and social parameters are involved. Recently, regular and fun sports exercises and the use of some herbal medicines have been considered by researchers as the recommended treatment options for this syndrome. Therefore, this study aimed to investigate the effect of a selected period of exercise training and consumption of Vitex Agnus Castus extract on the psychological and physical symptoms of premenstrual syndrome in young girls. Method: This research was a quasi-experimental study conducted among female students living in Gachsaran Azad University dormitories. In this study, out of 75 female students with PMS who had the conditions to enter the study, 40 people were randomly selected and divided into 4 groups of 10 people, including:1) Aerobic Training, 2)Vitex extract consumption, 3)Aerobic Training+ Vitex, and 4) control. The training group performed 3 sessions per week for 8 weeks and 35 to 45 minutes each session at a maximum intensity of 55 to 65% of maximum heart rate. The Vitex group took 40 drops of Vitex Agnus Castus before breakfast with juice and six days before menstruation up to menstruation for two consecutive cycles. At the end of the eighth week, the PMS questionnaire was completed again by the subjects and the data analysis was performed in SPSS using multivariate analysis of variance (MANOVA)at P≤0.05. Results: Eight weeks of aerobic training and consumption of Vitex extract had a significant effect on the psychological (P≤0.05) and physical (P≤0.05) symptoms of intervention groups compared to the control group (P≤0.05), but there was no significant difference between some intervention groups in terms of reducing physical symptoms(P≤0.05). Also, the effects of treatment in the Vitex+ Training group and the Vitex consumption group were higher than the Aerobic Training group (P≤0.05). Conclusion: Regarding the fun nature of exercises and low cost and low side effects of Vitexextract, it is recommended that young girls use aerobic training and Vitexextractas as an alternative treatment to treat and reduce PMS symptoms.


1. Samadi Z, Taghian F, Valiani M. Comparison of two different methods of Pilates, aerobic and symptoms of premenstrual syndrome in female non-athletes. Journal of Isfahan Medical School 2012;30(213):1-12.[Persian].
2.Tempel R. PMS in the workplace. An occupational health nurse's guide to premenstrual syndrome. AAOHN J. 2001;11(4):473-9. PMID: 11760268
3. Rajaeyan A, Norshahi L, Zahedi H. Examine the relationship between the prevalence of premenstrual syndrome with non Vrshkar aerobic capacity and athletic girls, martyr Beheshti University.2011:16-24.[Persian].
4. Ozgoli G, Selselei EA, Mojab F, Majd HA. A randomized, placebocontrolled trial of Ginkgo biloba L. in treatment of premenstrual syndrome. J Altern Complement Med 2009;15(8):845-51. DOI: 10.1089/acm.2008.0493.
5. Webster, D.E.; J. Lu, S.-N. Chen, N.R. Farnsworth and Z. Jim Wang (2006). “Activation of the μ-opiate receptor by Vitexagnus-castus methanol extracts: Implication for its use in PMS”. Journal of Ethnopharmacology 106 (2): 216-221. DOI: 10.1016/j.jep.2005.12.025
6- Wuttke, W; Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D. (May 2003). “Chaste tree (Vitexagnus-castus)–pharmacology and clinical indications”. ExpClinEndocrinol Diabetes 10 (4): 348-57.
7. Sabaei Y, Sabaei S, Khorshidi D, Ebrahimpour S, Fallah-Rostami F. The Association between Premenstrual Syndrome and Physical Activity and Aerobic Power in Female High School Students. Crescent J Med and Biol Sci 2015; 2: 53-8. CJMB 2015; 2: 053-058
8. Ruprai RK, Kurwale M, Mankar S. The effect of regular 4 months aerobic exercises on premenstrual syndrome on healthy females. Indian J Basic Appl Med Res 2015; 4(2):340-4.
9. Nikbakhat M, Ebadi GH. The comparison between run and walking exercises effects on PMS of student of high school in Ahvaz. Research on Sport Sciences 2007;14:55-70.[Persian].
10. Mosallanejad Z, Gaeini AA, Mosallanejad L. The effect of continuous aerobic exercise on premenstrual syndrome: a randomized clinical trial. TUMJ 2007;65(1):49-53. URL:          
11. Ali abedy H, Neksereshgt A, Tashakoriyan F. The effects of resistance and endurance exercise on physical and psychobehavioral symptoms of pre-menstruation syndrome. Par J Med Sci 2014; 12: 9-14. [Persian]
12.Azhary S, Karimi Chatrudi A, Attarzadeh R, Mazloom R. Officacy of group aerobic exercise program on the intensity of premenstrual syndrome. Iran J Obstet Gynecol Infertil. 2005;8(2):28-119.[In Persian].
13. Fotokian Z,Ghaffari F. Aerobic exercise program on the intensity of premenstrual syndrome. Iran J Dermatol 2006;8(4):76-80. URL:
14. Homai HM,Shafai FS, Zoodfekr L. Comparing menarche age, Menstrual regularity, Dysmenorrhea and analgesic consumption among athletic  and non- athletic   female students at university of Tabriz-Iran. Int J Womens Health Reprod Sci 2014; 2:307-10.
15. Zamani M,  Neghab N,  Torabian S. Therapeutic Effect of Vitex Agnus Castus in Patients With Premenstrual Syndrome.Jornal of Acta Med Iran 2012;50(2):101-6. PMID: 22359078
16. Nikbakht M, Alijani A. Comparison of eight weeks of aerobic exercise and vitamin B6 non-athletic female Mszf on PMS symptoms university Martyr Chamran. Journal of Motion 2006; (28):57-68.[Persian].
17.Kariman NS, Rezaian M, Nassaji F, Valaei N, Gachkar L. The effect of exercise in premenstrual syndrome. J Zanjan Univ Med Sci. 2005;13(53):8-15.[In Persian].
18.Samadi Z, Taghian F, Valiani F. The effects of weeks of regular aerobic exercise on the symptoms of premenstrual syndrome in non-athlete girls. Iran J Nurs Midwifery Res. 2013;18(1):14-9. PMID: 23983722
19. Safavi Naeini Kh. The comparison between aerobic and physical exercises effects on PMS of women in Shiraz. Medical Sciences Journal of Islamic Azad University 2008;18(3):177-80.[Persian].
20. Moghadasi A. A comparison of prevalence of premenstrual syndrome symptoms between athlete an d non-athlete female students. Physiology of Sport and Physical Activity 2009;3:199- 208.[Persian]
21. Mohamadi B, Azimian Jazi A, Faramarzi M, Fatholahishorabeh F. The effect of aerobic exercise on premenstrual symptoms of nonathlete students. Horizon Journal of Medical Sciences and Health Services Gonabad 2012;18(2) .[Persian].
22. Bidokhti H, Heaidari M, Mehri F. Effects of soy on physical and behavioral and psychological symptoms of premenstrual syndrome in female students of Semnan. Journal of Nursing and Midwifery Uromeaia 2013;15:316-323.[Persian].
24. Khayat S, Kheirkhah M, Fanaei H, Behboodi Moghadam Z, Pourmohsen M, Kasaeiyan A. Comparison theeffects of ginger and curcumin in treatment of premenstrual syndrome. Iran South Med J 2014; 18(3):575-86.Persian).