Endurance Training and Royal Jelly Consumption Effects on Dopamine in Rats with Alzheimer's disease

Document Type : Research Paper


Department of Physical Education and Sport Sciences, Eslamshahr Branch, Islamic Azad University, Eslamshahr, Iran


Introduction: Alzheimer's disease may be a sort of amnesia with brain dysfunction that gradually degrades the patient's mental abilities. The purpose of this study was to research the effect of endurance training with royal jelly consumption on dopamine in the hippocampus tissue of Alzheimer's rats with trimethyltin. Methods: During this study, 30 rats underwent injection of 8 milligram / Kilograms trimethyltin chloride and were divided into groups of 6 rats: control, training, royal jelly consumption, and training with royal jelly consumption. 6 rats were included in the healthy control group to be evaluated the effects of Alzheimer's induction on dopamine levels. The training groups were active on the treadmill for 8 weeks. The royal jelly consumption groups received 100 milligram / Kilograms royal jelly per day peritoneally for 8 weeks. The Kolmogorov-Smirnov, one-way ANOVA, and Tukey’s post hoc tests were used to analyze the findings. (P ≤0.05). Results: Alzheimer's induction with trimethyltin toxin had a Significant Impact on reducing dopamine gene levels (P = 0.04); royal jelly, training, and training with royal jelly consumption had a significant effect on increasing dopamine gene expression levels (P = 0.001). Also, the effect of training with Royal Jelly was greater than training or royal jelly consumption alone. (P = 0.001) Conclusions: Although training and royal jelly consumption improve dopamine gene expression levels in the hippocampus tissue of rats with Alzheimer's disease, the effects of training combined with royal jelly consumption appear to be greater than those of royal jelly consumption alone.


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